Hurst DP - Search Results

1

Pregnenolone can protect the brain from cannabis intoxication.

Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV. Vallée M, et al. Among authors: hurst dp. Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985. Science. 2014. PMID: 24385629 Free PMC article.

2

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.

Barnett-Norris J, Hurst DP, Lynch DL, Guarnieri F, Makriyannis A, Reggio PH. Barnett-Norris J, et al. Among authors: hurst dp. J Med Chem. 2002 Aug 15;45(17):3649-59. doi: 10.1021/jm0200761. J Med Chem. 2002. PMID: 12166938

3

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.

Hurst DP, Lynch DL, Barnett-Norris J, Hyatt SM, Seltzman HH, Zhong M, Song ZH, Nie J, Lewis D, Reggio PH. Hurst DP, et al. Mol Pharmacol. 2002 Dec;62(6):1274-87. doi: 10.1124/mol.62.6.1274. Mol Pharmacol. 2002. PMID: 12435794

4

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch.

Singh R, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Guarnieri F. Singh R, et al. Among authors: hurst dp. J Pept Res. 2002 Dec;60(6):357-70. doi: 10.1034/j.1399-3011.2002.21065.x. J Pept Res. 2002. PMID: 12464114

5

An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.

McAllister SD, Rizvi G, Anavi-Goffer S, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Abood ME. McAllister SD, et al. Among authors: hurst dp. J Med Chem. 2003 Nov 20;46(24):5139-52. doi: 10.1021/jm0302647. J Med Chem. 2003. PMID: 14613317

6

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.

McAllister SD, Hurst DP, Barnett-Norris J, Lynch D, Reggio PH, Abood ME. McAllister SD, et al. Among authors: hurst dp. J Biol Chem. 2004 Nov 12;279(46):48024-37. doi: 10.1074/jbc.M406648200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326174 Free article.

7

Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template.

Zhang R, Hurst DP, Barnett-Norris J, Reggio PH, Song ZH. Zhang R, et al. Among authors: hurst dp. Mol Pharmacol. 2005 Jul;68(1):69-83. doi: 10.1124/mol.104.007823. Epub 2005 Apr 19. Mol Pharmacol. 2005. PMID: 15840841

8

Adamantyl cannabinoids: a novel class of cannabinergic ligands.

Lu D, Meng Z, Thakur GA, Fan P, Steed J, Tartal CL, Hurst DP, Reggio PH, Deschamps JR, Parrish DA, George C, Järbe TU, Lamb RJ, Makriyannis A. Lu D, et al. Among authors: hurst dp. J Med Chem. 2005 Jul 14;48(14):4576-85. doi: 10.1021/jm058175c. J Med Chem. 2005. PMID: 15999995

9

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.

Picone RP, Khanolkar AD, Xu W, Ayotte LA, Thakur GA, Hurst DP, Abood ME, Reggio PH, Fournier DJ, Makriyannis A. Picone RP, et al. Among authors: hurst dp. Mol Pharmacol. 2005 Dec;68(6):1623-35. doi: 10.1124/mol.105.014407. Epub 2005 Sep 12. Mol Pharmacol. 2005. PMID: 16157695

10

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7.

Kapur A, Hurst DP, Fleischer D, Whitnell R, Thakur GA, Makriyannis A, Reggio PH, Abood ME. Kapur A, et al. Among authors: hurst dp. Mol Pharmacol. 2007 Jun;71(6):1512-24. doi: 10.1124/mol.107.034645. Epub 2007 Mar 23. Mol Pharmacol. 2007. PMID: 17384224

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