Hurley LH - Search Results

1

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.

Brooks TA, Hurley LH. Brooks TA, et al. Among authors: hurley lh. Nat Rev Cancer. 2009 Dec;9(12):849-61. doi: 10.1038/nrc2733. Epub 2009 Nov 12. Nat Rev Cancer. 2009. PMID: 19907434 Review.

2

Targeting MYC Expression through G-Quadruplexes.

Brooks TA, Hurley LH. Brooks TA, et al. Among authors: hurley lh. Genes Cancer. 2010 Jun;1(6):641-649. doi: 10.1177/1947601910377493. Genes Cancer. 2010. PMID: 21113409 Free PMC article.

3

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.

Brown RV, Danford FL, Gokhale V, Hurley LH, Brooks TA. Brown RV, et al. Among authors: hurley lh. J Biol Chem. 2011 Nov 25;286(47):41018-27. doi: 10.1074/jbc.M111.274720. Epub 2011 Sep 28. J Biol Chem. 2011. PMID: 21956115 Free PMC article.

4

Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.

Boddupally PV, Hahn S, Beman C, De B, Brooks TA, Gokhale V, Hurley LH. Boddupally PV, et al. Among authors: hurley lh. J Med Chem. 2012 Jul 12;55(13):6076-86. doi: 10.1021/jm300282c. Epub 2012 Jun 25. J Med Chem. 2012. PMID: 22691117 Free PMC article.

5

Making sense of G-quadruplex and i-motif functions in oncogene promoters.

Brooks TA, Kendrick S, Hurley L. Brooks TA, et al. FEBS J. 2010 Sep;277(17):3459-69. doi: 10.1111/j.1742-4658.2010.07759.x. Epub 2010 Jul 29. FEBS J. 2010. PMID: 20670278 Free PMC article. Review.

6

Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression.

Qin Y, Fortin JS, Tye D, Gleason-Guzman M, Brooks TA, Hurley LH. Qin Y, et al. Among authors: hurley lh. Biochemistry. 2010 May 18;49(19):4208-19. doi: 10.1021/bi100330w. Biochemistry. 2010. PMID: 20377208 Free PMC article.

7

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).

Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH. Dexheimer TS, et al. Among authors: hurley lh. Mol Cancer Ther. 2009 May;8(5):1363-77. doi: 10.1158/1535-7163.MCT-08-1093. Epub 2009 May 12. Mol Cancer Ther. 2009. PMID: 19435876 Free PMC article.

8

The c-MYC NHE III(1): function and regulation.

González V, Hurley LH. González V, et al. Among authors: hurley lh. Annu Rev Pharmacol Toxicol. 2010;50:111-29. doi: 10.1146/annurev.pharmtox.48.113006.094649. Annu Rev Pharmacol Toxicol. 2010. PMID: 19922264 Review.

9

The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.

Sun D, Hurley LH. Sun D, et al. Among authors: hurley lh. J Med Chem. 2009 May 14;52(9):2863-74. doi: 10.1021/jm900055s. J Med Chem. 2009. PMID: 19385599 Free PMC article.

10

Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.

González V, Guo K, Hurley L, Sun D. González V, et al. J Biol Chem. 2009 Aug 28;284(35):23622-35. doi: 10.1074/jbc.M109.018028. Epub 2009 Jul 6. J Biol Chem. 2009. PMID: 19581307 Free PMC article.

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