Hurle MR - Search Results

1

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

Zheng J, Haberland V, Baird D, Walker V, Haycock PC, Hurle MR, Gutteridge A, Erola P, Liu Y, Luo S, Robinson J, Richardson TG, Staley JR, Elsworth B, Burgess S, Sun BB, Danesh J, Runz H, Maranville JC, Martin HM, Yarmolinsky J, Laurin C, Holmes MV, Liu JZ, Estrada K, Santos R, McCarthy L, Waterworth D, Nelson MR, Smith GD, Butterworth AS, Hemani G, Scott RA, Gaunt TR. Zheng J, et al. Among authors: hurle mr. Nat Genet. 2020 Oct;52(10):1122-1131. doi: 10.1038/s41588-020-0682-6. Epub 2020 Sep 7. Nat Genet. 2020. PMID: 32895551 Free PMC article.

2

Network and pathway expansion of genetic disease associations identifies successful drug targets.

MacNamara A, Nakic N, Amin Al Olama A, Guo C, Sieber KB, Hurle MR, Gutteridge A. MacNamara A, et al. Among authors: hurle mr. Sci Rep. 2020 Dec 1;10(1):20970. doi: 10.1038/s41598-020-77847-9. Sci Rep. 2020. PMID: 33262371 Free PMC article.

3

Predicting clinically promising therapeutic hypotheses using tensor factorization.

Yao J, Hurle MR, Nelson MR, Agarwal P. Yao J, et al. Among authors: hurle mr. BMC Bioinformatics. 2019 Feb 8;20(1):69. doi: 10.1186/s12859-019-2664-1. BMC Bioinformatics. 2019. PMID: 30736745 Free PMC article.

4

Trial watch: Impact of genetically supported target selection on R&D productivity.

Hurle MR, Nelson MR, Agarwal P, Cardon LR. Hurle MR, et al. Nat Rev Drug Discov. 2016 Aug 30;15(9):596-597. doi: 10.1038/nrd.2016.164. Nat Rev Drug Discov. 2016. PMID: 27573226 No abstract available.

5

Impact of genetically supported target selection on R&D productivity.

Hurle MR, Nelson MR, Agarwal P, Cardon LR. Hurle MR, et al. Nat Rev Drug Discov. 2016 Sep 12;15(9):596-597. doi: 10.1038/nrd.2016.187. Nat Rev Drug Discov. 2016. PMID: 28184040

6

Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities.

Jhamb D, Magid-Slav M, Hurle MR, Agarwal P. Jhamb D, et al. Among authors: hurle mr. Drug Discov Today. 2019 Jun;24(6):1232-1236. doi: 10.1016/j.drudis.2019.03.024. Epub 2019 Mar 29. Drug Discov Today. 2019. PMID: 30935985

7

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues.

Kumar V, Sanseau P, Simola DF, Hurle MR, Agarwal P. Kumar V, et al. Among authors: hurle mr. Sci Rep. 2016 Nov 8;6:36205. doi: 10.1038/srep36205. Sci Rep. 2016. PMID: 27824084 Free PMC article.

8

Combined Analysis of Phenotypic and Target-Based Screening in Assay Networks.

Swamidass SJ, Schillebeeckx CN, Matlock M, Hurle MR, Agarwal P. Swamidass SJ, et al. Among authors: hurle mr. J Biomol Screen. 2014 Jun;19(5):782-90. doi: 10.1177/1087057114523068. Epub 2014 Feb 21. J Biomol Screen. 2014. PMID: 24563424

9

Computational drug repositioning: from data to therapeutics.

Hurle MR, Yang L, Xie Q, Rajpal DK, Sanseau P, Agarwal P. Hurle MR, et al. Clin Pharmacol Ther. 2013 Apr;93(4):335-41. doi: 10.1038/clpt.2013.1. Epub 2013 Jan 15. Clin Pharmacol Ther. 2013. PMID: 23443757 Review.

10

Evaluation of analytical methods for connectivity map data.

Cheng J, Xie Q, Kumar V, Hurle M, Freudenberg JM, Yang L, Agarwal P. Cheng J, et al. Pac Symp Biocomput. 2013:5-16. Pac Symp Biocomput. 2013. PMID: 23424107 Free article.

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