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Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A.
Lee H, Kim E, Hwang N, Yoo J, Nam Y, Hwang I, Park JG, Park SE, Chung KS, Won Chung H, Song C, Ji MJ, Park HM, Lee IK, Lee KT, Joo Roh E, Hur W. Lee H, et al. Among authors: hur w. Bioorg Med Chem. 2024 Mar 15;102:117658. doi: 10.1016/j.bmc.2024.117658. Epub 2024 Feb 27. Bioorg Med Chem. 2024. PMID: 38460487
Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant.
El-Damasy AK, Kim HJ, Park JW, Nam Y, Hur W, Bang EK, Keum G. El-Damasy AK, et al. Among authors: hur w. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2228515. doi: 10.1080/14756366.2023.2228515. J Enzyme Inhib Med Chem. 2023. PMID: 37470410 Free PMC article.
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Strilchuk AW, Hur WS, Batty P, Sang Y, Abrahams SR, Yong ASM, Leung J, Silva LM, Schroeder JA, Nesbitt K, de Laat B, Moutsopoulos NM, Bugge TH, Shi Q, Cullis PR, Merricks EP, Wolberg AS, Flick MJ, Lillicrap D, Nichols TC, Kastrup CJ. Strilchuk AW, et al. Among authors: hur ws. Sci Transl Med. 2024 Feb 21;16(735):eadh0027. doi: 10.1126/scitranslmed.adh0027. Epub 2024 Feb 21. Sci Transl Med. 2024. PMID: 38381848
230 results