Huo Y - Search Results

1

Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.

Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B. Huo Y, et al. Cancer Discov. 2013 Aug;3(8):894-907. doi: 10.1158/2159-8290.CD-13-0011. Epub 2013 May 6. Cancer Discov. 2013. PMID: 23650262 Free PMC article.

2

Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.

Simhadri S, Peterson S, Patel DS, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting SF, Jasin M, Xia B. Simhadri S, et al. Among authors: huo y. J Biol Chem. 2014 Aug 29;289(35):24617-29. doi: 10.1074/jbc.M114.566141. Epub 2014 Jul 11. J Biol Chem. 2014. PMID: 25016020 Free PMC article.

3

Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1-PALB2 Interaction.

Mahdi AH, Huo Y, Tan Y, Simhadri S, Vincelli G, Gao J, Ganesan S, Xia B. Mahdi AH, et al. Among authors: huo y. Cancer Res. 2018 Jul 15;78(14):3969-3981. doi: 10.1158/0008-5472.CAN-18-0388. Epub 2018 May 8. Cancer Res. 2018. PMID: 29739757 Free PMC article.

4

Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.

Foo TK, Tischkowitz M, Simhadri S, Boshari T, Zayed N, Burke KA, Berman SH, Blecua P, Riaz N, Huo Y, Ding YC, Neuhausen SL, Weigelt B, Reis-Filho JS, Foulkes WD, Xia B. Foo TK, et al. Among authors: huo y. Oncogene. 2017 Jul 20;36(29):4161-4170. doi: 10.1038/onc.2017.46. Epub 2017 Mar 20. Oncogene. 2017. PMID: 28319063 Free PMC article.

5

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.

Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN, Zhang DD, Xia B. Ma J, et al. Among authors: huo y. Mol Cell Biol. 2012 Apr;32(8):1506-17. doi: 10.1128/MCB.06271-11. Epub 2012 Feb 13. Mol Cell Biol. 2012. PMID: 22331464 Free PMC article.

6

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response.

Simhadri S, Vincelli G, Huo Y, Misenko S, Foo TK, Ahlskog J, Sørensen CS, Oakley GG, Ganesan S, Bunting SF, Xia B. Simhadri S, et al. Among authors: huo y. Oncogene. 2019 Mar;38(10):1585-1596. doi: 10.1038/s41388-018-0535-2. Epub 2018 Oct 18. Oncogene. 2019. PMID: 30337689 Free PMC article.

7

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development.

Huo Y, Selenica P, Mahdi AH, Pareja F, Kyker-Snowman K, Chen Y, Kumar R, Da Cruz Paula A, Basili T, Brown DN, Pei X, Riaz N, Tan Y, Huang YX, Li T, Barnard NJ, Reis-Filho JS, Weigelt B, Xia B. Huo Y, et al. NPJ Breast Cancer. 2021 Apr 23;7(1):45. doi: 10.1038/s41523-021-00253-5. NPJ Breast Cancer. 2021. PMID: 33893322 Free PMC article.

8

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration.

Huo Y, Sawant A, Tan Y, Mahdi AH, Li T, Ma H, Bhatt V, Yan R, Coleman J, Dreyfus CF, Guo JY, Mouradian MM, White E, Xia B. Huo Y, et al. PLoS Genet. 2022 Apr 11;18(4):e1010138. doi: 10.1371/journal.pgen.1010138. eCollection 2022 Apr. PLoS Genet. 2022. PMID: 35404932 Free PMC article.

9

Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice.

Mahdi AH, Huo Y, Chen Y, Selenica P, Sharma A, Merritt E, Barnard N, Chan C, Ganesan S, Reis-Filho JS, Weigelt B, De S, Xia B. Mahdi AH, et al. Among authors: huo y. Genes Dis. 2020 Sep 5;9(3):807-813. doi: 10.1016/j.gendis.2020.08.012. eCollection 2022 May. Genes Dis. 2020. PMID: 35782971 Free PMC article.

10

ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G₂-M Checkpoint Maintenance.

Foo TK, Vincelli G, Huselid E, Her J, Zheng H, Simhadri S, Wang M, Huo Y, Li T, Yu X, Li H, Zhao W, Bunting SF, Xia B. Foo TK, et al. Among authors: huo y. Cancer Res. 2021 Sep 15;81(18):4676-4684. doi: 10.1158/0008-5472.CAN-20-2723. Epub 2021 Jul 23. Cancer Res. 2021. PMID: 34301763 Free PMC article.

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