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A major predisposition locus for severe obesity, at 4p15-p14.
Stone S, Abkevich V, Hunt SC, Gutin A, Russell DL, Neff CD, Riley R, Frech GC, Hensel CH, Jammulapati S, Potter J, Sexton D, Tran T, Gibbs D, Iliev D, Gress R, Bloomquist B, Amatruda J, Rae PM, Adams TD, Skolnick MH, Shattuck D. Stone S, et al. Among authors: hunt sc. Am J Hum Genet. 2002 Jun;70(6):1459-68. doi: 10.1086/340670. Epub 2002 Apr 15. Am J Hum Genet. 2002. PMID: 11957135 Free PMC article.
Design and rationale of the Utah obesity study. A study to assess morbidity following gastric bypass surgery.
Adams TD, Avelar E, Cloward T, Crosby RD, Farney RJ, Gress R, Halverson RC, Hopkins PN, Kolotkin RL, Lamonte MJ, Litwin S, Nuttall RT, Pendleton R, Rosamond W, Simper SC, Smith SC, Strong M, Walker JM, Wiebke G, Yanowitz FG, Hunt SC. Adams TD, et al. Among authors: hunt sc. Contemp Clin Trials. 2005 Oct;26(5):534-51. doi: 10.1016/j.cct.2005.05.003. Contemp Clin Trials. 2005. PMID: 16046191 Clinical Trial.
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.
Stone S, Abkevich V, Russell DL, Riley R, Timms K, Tran T, Trem D, Frank D, Jammulapati S, Neff CD, Iliev D, Gress R, He G, Frech GC, Adams TD, Skolnick MH, Lanchbury JS, Gutin A, Hunt SC, Shattuck D. Stone S, et al. Among authors: hunt sc. Hum Mol Genet. 2006 Sep 15;15(18):2709-20. doi: 10.1093/hmg/ddl204. Epub 2006 Aug 7. Hum Mol Genet. 2006. PMID: 16893906
422 results