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A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation.
Fletcher A, Clift D, de Vries E, Martinez Cuesta S, Malcolm T, Meghini F, Chaerkady R, Wang J, Chiang A, Weng SHS, Tart J, Wong E, Donohoe G, Rawlins P, Gordon E, Taylor JD, James L, Hunt J. Fletcher A, et al. Among authors: hunt j. Nat Commun. 2023 Nov 4;14(1):7093. doi: 10.1038/s41467-023-42546-2. Nat Commun. 2023. PMID: 37925433 Free PMC article.
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure.
De Genst E, Foo KS, Xiao Y, Rohner E, de Vries E, Sohlmér J, Witman N, Hidalgo A, Kolstad TRS, Louch WE, Pehrsson S, Park A, Ikeda Y, Li X, Mayr LM, Wickson K, Jennbacken K, Hansson K, Fritsche-Danielson R, Hunt J, Chien KR. De Genst E, et al. Among authors: hunt j. Nat Commun. 2022 May 31;13(1):3018. doi: 10.1038/s41467-022-29703-9. Nat Commun. 2022. PMID: 35641497 Free PMC article.
Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies.
Lawson NL, Dix CI, Scorer PW, Stubbs CJ, Wong E, Hutchinson L, McCall EJ, Schimpl M, DeVries E, Walker J, Williams GH, Hunt J, Barker C. Lawson NL, et al. Among authors: hunt j. Mod Pathol. 2020 Apr;33(4):518-530. doi: 10.1038/s41379-019-0372-z. Epub 2019 Sep 26. Mod Pathol. 2020. PMID: 31558782 Free PMC article.
Correction: Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies.
Lawson NL, Dix CI, Scorer PW, Stubbs CJ, Wong E, Hutchinson L, McCall EJ, Schimpl M, DeVries E, Walker J, Williams GH, Hunt J, Barker C. Lawson NL, et al. Among authors: hunt j. Mod Pathol. 2020 Apr;33(4):758. doi: 10.1038/s41379-019-0379-5. Mod Pathol. 2020. PMID: 31641230 Free PMC article.
Selective CRAF Inhibition Elicits Transactivation.
Morgan CW, Dale IL, Thomas AP, Hunt J, Chin JW. Morgan CW, et al. Among authors: hunt j. J Am Chem Soc. 2021 Mar 31;143(12):4600-4606. doi: 10.1021/jacs.0c11958. Epub 2021 Mar 22. J Am Chem Soc. 2021. PMID: 33750116 Free PMC article.
3,684 results