Hunt HJ - Search Results

1

Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.

Viho EMG, Buurstede JC, Mahfouz A, Koorneef LL, van Weert LTCM, Houtman R, Hunt HJ, Kroon J, Meijer OC. Viho EMG, et al. Among authors: hunt hj. Neuroendocrinology. 2019;109(3):266-276. doi: 10.1159/000499659. Epub 2019 Mar 19. Neuroendocrinology. 2019. PMID: 30884490 Free PMC article. Review.

2

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.

Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff JK, Lucassen PJ, Joëls M, de Kloet ER, Roozendaal B, Hunt H, Meijer OC. Zalachoras I, et al. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5. doi: 10.1073/pnas.1219411110. Epub 2013 Apr 23. Proc Natl Acad Sci U S A. 2013. PMID: 23613579 Free PMC article.

3

The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice.

Meyer M, Gonzalez Deniselle MC, Hunt H, de Kloet ER, De Nicola AF. Meyer M, et al. J Steroid Biochem Mol Biol. 2014 Sep;143:40-8. doi: 10.1016/j.jsbmb.2014.02.007. Epub 2014 Feb 22. J Steroid Biochem Mol Biol. 2014. PMID: 24565565

4

A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain.

Atucha E, Zalachoras I, van den Heuvel JK, van Weert LT, Melchers D, Mol IM, Belanoff JK, Houtman R, Hunt H, Roozendaal B, Meijer OC. Atucha E, et al. Endocrinology. 2015 Nov;156(11):4105-14. doi: 10.1210/en.2015-1390. Epub 2015 Aug 25. Endocrinology. 2015. PMID: 26305887

5

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.

van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, van Dijk KW, Pereira AM, Hunt H, Belanoff JK, Rensen PC, Meijer OC. van den Heuvel JK, et al. Br J Pharmacol. 2016 Jun;173(11):1793-804. doi: 10.1111/bph.13477. Epub 2016 Apr 24. Br J Pharmacol. 2016. PMID: 26990179 Free PMC article.

6

New selective glucocorticoid receptor modulators reverse amyloid-β peptide-induced hippocampus toxicity.

Pineau F, Canet G, Desrumaux C, Hunt H, Chevallier N, Ollivier M, Belanoff JK, Givalois L. Pineau F, et al. Neurobiol Aging. 2016 Sep;45:109-122. doi: 10.1016/j.neurobiolaging.2016.05.018. Epub 2016 May 27. Neurobiol Aging. 2016. PMID: 27459932

7

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.

Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E. Hunt HJ, et al. J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28368581

8

Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice.

Kroon J, Koorneef LL, van den Heuvel JK, Verzijl CRC, van de Velde NM, Mol IM, Sips HCM, Hunt H, Rensen PCN, Meijer OC. Kroon J, et al. Endocrinology. 2018 Jan 1;159(1):535-546. doi: 10.1210/en.2017-00512. Endocrinology. 2018. PMID: 28938459

9

The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord.

Meyer M, Lara A, Hunt H, Belanoff J, de Kloet ER, Gonzalez Deniselle MC, De Nicola AF. Meyer M, et al. Neuroscience. 2018 Aug 1;384:384-396. doi: 10.1016/j.neuroscience.2018.05.042. Epub 2018 Jun 8. Neuroscience. 2018. PMID: 29890290

10

Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice.

Koorneef LL, van den Heuvel JK, Kroon J, Boon MR, 't Hoen PAC, Hettne KM, van de Velde NM, Kolenbrander KB, Streefland TCM, Mol IM, Sips HCM, Kielbasa SM, Mei H, Belanoff JK, Pereira AM, Oosterveer MH, Hunt H, Rensen PCN, Meijer OC. Koorneef LL, et al. Endocrinology. 2018 Dec 1;159(12):3925-3936. doi: 10.1210/en.2018-00671. Endocrinology. 2018. PMID: 30321321

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