Humpton TJ - Search Results

1

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. DeNicola GM, et al. Among authors: humpton tj. Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189. Nature. 2011. PMID: 21734707 Free PMC article.

2

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.

Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA. Humpton TJ, et al. Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. Epub 2019 Jul 1. Cancer Discov. 2019. PMID: 31263025 Free PMC article.

3

Regulation of Cellular Metabolism and Hypoxia by p53.

Humpton TJ, Vousden KH. Humpton TJ, et al. Cold Spring Harb Perspect Med. 2016 Jul 1;6(7):a026146. doi: 10.1101/cshperspect.a026146. Cold Spring Harb Perspect Med. 2016. PMID: 27371670 Free PMC article. Review.

4

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo.

Hock AK, Cheung EC, Humpton TJ, Monteverde T, Paulus-Hock V, Lee P, McGhee E, Scopelliti A, Murphy DJ, Strathdee D, Blyth K, Vousden KH. Hock AK, et al. Among authors: humpton tj. Sci Rep. 2017 May 12;7(1):1837. doi: 10.1038/s41598-017-01741-0. Sci Rep. 2017. PMID: 28500323 Free PMC article.

5

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3.

Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH. Tajan M, et al. Among authors: humpton tj. Cell Metab. 2018 Nov 6;28(5):721-736.e6. doi: 10.1016/j.cmet.2018.07.005. Epub 2018 Aug 16. Cell Metab. 2018. PMID: 30122553 Free PMC article.

6

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant.

Humpton TJ, Hock AK, Maddocks ODK, Vousden KH. Humpton TJ, et al. Cancer Metab. 2018 Dec 3;6:18. doi: 10.1186/s40170-018-0191-6. eCollection 2018. Cancer Metab. 2018. PMID: 30524726 Free PMC article.

7

Taking up the reins of power: metabolic functions of p53.

Humpton T, Vousden KH. Humpton T, et al. J Mol Cell Biol. 2019 Jul 19;11(7):610-614. doi: 10.1093/jmcb/mjz065. J Mol Cell Biol. 2019. PMID: 31282931 Free PMC article. Review. No abstract available.

8

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.

Humpton TJ, Nomura K, Weber J, Magnussen HM, Hock AK, Nixon C, Dhayade S, Stevenson D, Huang DT, Strathdee D, Blyth K, Vousden KH. Humpton TJ, et al. Genes Dev. 2021 Jan 1;35(1-2):117-132. doi: 10.1101/gad.341875.120. Epub 2020 Dec 17. Genes Dev. 2021. PMID: 33334825 Free PMC article.

9

p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl₄.

Humpton TJ, Hall H, Kiourtis C, Nixon C, Clark W, Hedley A, Shaw R, Bird TG, Blyth K, Vousden KH. Humpton TJ, et al. Cell Death Differ. 2022 Mar;29(3):514-526. doi: 10.1038/s41418-021-00871-3. Epub 2021 Oct 9. Cell Death Differ. 2022. PMID: 34628485 Free PMC article.

10

A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo.

Humpton TJ, Hock AK, Kiourtis C, De Donatis M, Fercoq F, Nixon C, Bryson S, Strathdee D, Carlin LM, Bird TG, Blyth K, Vousden KH. Humpton TJ, et al. Sci Signal. 2022 Feb 8;15(720):eabd9099. doi: 10.1126/scisignal.abd9099. Epub 2022 Feb 8. Sci Signal. 2022. PMID: 35133863 Free PMC article.

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