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Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1.
Clement M, Ladell K, Miners KL, Marsden M, Chapman L, Cardus Figueras A, Scott J, Andrews R, Clare S, Kriukova VV, Lupyr KR, Britanova OV, Withers DR, Jones SA, Chudakov DM, Price DA, Humphreys IR. Clement M, et al. Among authors: humphreys ir. Elife. 2023 Jul 13;12:e79165. doi: 10.7554/eLife.79165. Elife. 2023. PMID: 37440306 Free PMC article.
IL-10 restricts memory T cell inflation during cytomegalovirus infection.
Jones M, Ladell K, Wynn KK, Stacey MA, Quigley MF, Gostick E, Price DA, Humphreys IR. Jones M, et al. Among authors: humphreys ir. J Immunol. 2010 Sep 15;185(6):3583-92. doi: 10.4049/jimmunol.1001535. Epub 2010 Aug 16. J Immunol. 2010. PMID: 20713884 Free PMC article.
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.
Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR. Stacey MA, et al. Among authors: humphreys ir. Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003. Cell Host Microbe. 2014. PMID: 24721575 Free PMC article.
Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes.
Parkinson NJ, Roddis M, Ferneyhough B, Zhang G, Marsden AJ, Maslau S, Sanchez-Pearson Y, Barthlott T, Humphreys IR, Ladell K, Price DA, Ponting CP, Hollander G, Fischer MD. Parkinson NJ, et al. Among authors: humphreys ir. Genome Res. 2015 Feb;25(2):226-34. doi: 10.1101/gr.179770.114. Epub 2014 Nov 3. Genome Res. 2015. PMID: 25367293 Free PMC article.
CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.
Stack G, Jones E, Marsden M, Stacey MA, Snelgrove RJ, Lacaze P, Jacques LC, Cuff SM, Stanton RJ, Gallimore AM, Hussell T, Wilkinson GW, Ghazal P, Taylor PR, Humphreys IR. Stack G, et al. Among authors: humphreys ir. PLoS Pathog. 2015 Feb 5;11(2):e1004641. doi: 10.1371/journal.ppat.1004641. eCollection 2015 Feb. PLoS Pathog. 2015. PMID: 25654642 Free PMC article.
79 results