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TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life.
Davé E, Durrant O, Dhami N, Compson J, Broadbridge J, Archer S, Maroof A, Whale K, Menochet K, Bonnaillie P, Barry E, Wild G, Peerboom C, Bhatta P, Ellis M, Hinchliffe M, Humphreys DP, Heywood SP. Davé E, et al. Among authors: humphreys dp. MAbs. 2023 Jan-Dec;15(1):2160229. doi: 10.1080/19420862.2022.2160229. MAbs. 2023. PMID: 36788124 Free PMC article.
Alternative antibody Fab' fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering.
Humphreys DP, Heywood SP, Henry A, Ait-Lhadj L, Antoniw P, Palframan R, Greenslade KJ, Carrington B, Reeks DG, Bowering LC, West S, Brand HA. Humphreys DP, et al. Protein Eng Des Sel. 2007 May;20(5):227-34. doi: 10.1093/protein/gzm015. Epub 2007 Apr 23. Protein Eng Des Sel. 2007. PMID: 17452434
Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life.
Adams R, Griffin L, Compson JE, Jairaj M, Baker T, Ceska T, West S, Zaccheo O, Davé E, Lawson AD, Humphreys DP, Heywood S. Adams R, et al. Among authors: humphreys dp. MAbs. 2016 Oct;8(7):1336-1346. doi: 10.1080/19420862.2016.1185581. Epub 2016 Jun 17. MAbs. 2016. PMID: 27315033 Free PMC article.
Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding.
Davé E, Adams R, Zaccheo O, Carrington B, Compson JE, Dugdale S, Airey M, Malcolm S, Hailu H, Wild G, Turner A, Heads J, Sarkar K, Ventom A, Marshall D, Jairaj M, Kopotsha T, Christodoulou L, Zamacona M, Lawson AD, Heywood S, Humphreys DP. Davé E, et al. Among authors: humphreys dp. MAbs. 2016 Oct;8(7):1319-1335. doi: 10.1080/19420862.2016.1210747. Epub 2016 Aug 17. MAbs. 2016. PMID: 27532598 Free PMC article.
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions.
Qureshi OS, Rowley TF, Junker F, Peters SJ, Crilly S, Compson J, Eddleston A, Björkelund H, Greenslade K, Parkinson M, Davies NL, Griffin R, Pither TL, Cain K, Christodoulou L, Staelens L, Ward E, Tibbitts J, Kiessling A, Smith B, Brennan FR, Malmqvist M, Fallah-Arani F, Humphreys DP. Qureshi OS, et al. Among authors: humphreys dp. Sci Rep. 2017 Dec 6;7(1):17049. doi: 10.1038/s41598-017-17255-8. Sci Rep. 2017. PMID: 29213127 Free PMC article.
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