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Protective effect of different anti-rabies virus VHH constructs against rabies disease in mice.
Terryn S, Francart A, Lamoral S, Hultberg A, Rommelaere H, Wittelsberger A, Callewaert F, Stohr T, Meerschaert K, Ottevaere I, Stortelers C, Vanlandschoot P, Kalai M, Van Gucht S. Terryn S, et al. Among authors: hultberg a. PLoS One. 2014 Oct 27;9(10):e109367. doi: 10.1371/journal.pone.0109367. eCollection 2014. PLoS One. 2014. PMID: 25347556 Free PMC article.
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules.
Hultberg A, Temperton NJ, Rosseels V, Koenders M, Gonzalez-Pajuelo M, Schepens B, Ibañez LI, Vanlandschoot P, Schillemans J, Saunders M, Weiss RA, Saelens X, Melero JA, Verrips CT, Van Gucht S, de Haard HJ. Hultberg A, et al. PLoS One. 2011 Apr 1;6(4):e17665. doi: 10.1371/journal.pone.0017665. PLoS One. 2011. PMID: 21483777 Free PMC article.
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops.
van der Woning B, De Boeck G, Blanchetot C, Bobkov V, Klarenbeek A, Saunders M, Waelbroeck M, Laeremans T, Steyaert J, Hultberg A, De Haard H. van der Woning B, et al. Among authors: hultberg a. MAbs. 2016 Aug-Sep;8(6):1126-35. doi: 10.1080/19420862.2016.1189050. Epub 2016 May 21. MAbs. 2016. PMID: 27211075 Free PMC article.
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Klarenbeek A, El Mazouari K, Desmyter A, Blanchetot C, Hultberg A, de Jonge N, Roovers RC, Cambillau C, Spinelli S, Del-Favero J, Verrips T, de Haard HJ, Achour I. Klarenbeek A, et al. Among authors: hultberg a. MAbs. 2015;7(4):693-706. doi: 10.1080/19420862.2015.1046648. MAbs. 2015. PMID: 26018625 Free PMC article.
Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics.
Klarenbeek A, Blanchetot C, Schragel G, Sadi AS, Ongenae N, Hemrika W, Wijdenes J, Spinelli S, Desmyter A, Cambillau C, Hultberg A, Kretz-Rommel A, Dreier T, De Haard HJ, Roovers RC. Klarenbeek A, et al. Among authors: hultberg a. Protein Eng Des Sel. 2016 Apr;29(4):123-33. doi: 10.1093/protein/gzw003. Epub 2016 Mar 5. Protein Eng Des Sel. 2016. PMID: 26945588
28 results