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Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Annunziato S, de Ruiter JR, Henneman L, Brambillasca CS, Lutz C, Vaillant F, Ferrante F, Drenth AP, van der Burg E, Siteur B, van Gerwen B, de Bruijn R, van Miltenburg MH, Huijbers IJ, van de Ven M, Visvader JE, Lindeman GJ, Wessels LFA, Jonkers J. Annunziato S, et al. Among authors: huijbers ij. Nat Commun. 2019 Jan 23;10(1):397. doi: 10.1038/s41467-019-08301-2. Nat Commun. 2019. PMID: 30674894 Free PMC article.
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.
Henneman L, van Miltenburg MH, Michalak EM, Braumuller TM, Jaspers JE, Drenth AP, de Korte-Grimmerink R, Gogola E, Szuhai K, Schlicker A, Bin Ali R, Pritchard C, Huijbers IJ, Berns A, Rottenberg S, Jonkers J. Henneman L, et al. Among authors: huijbers ij. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8409-14. doi: 10.1073/pnas.1500223112. Epub 2015 Jun 22. Proc Natl Acad Sci U S A. 2015. PMID: 26100884 Free PMC article.
Using the GEMM-ESC strategy to study gene function in mouse models.
Huijbers IJ, Del Bravo J, Bin Ali R, Pritchard C, Braumuller TM, van Miltenburg MH, Henneman L, Michalak EM, Berns A, Jonkers J. Huijbers IJ, et al. Nat Protoc. 2015 Nov;10(11):1755-85. doi: 10.1038/nprot.2015.114. Epub 2015 Oct 15. Nat Protoc. 2015. PMID: 26492136
Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.
Annunziato S, Kas SM, Nethe M, Yücel H, Del Bravo J, Pritchard C, Bin Ali R, van Gerwen B, Siteur B, Drenth AP, Schut E, van de Ven M, Boelens MC, Klarenbeek S, Huijbers IJ, van Miltenburg MH, Jonkers J. Annunziato S, et al. Among authors: huijbers ij. Genes Dev. 2016 Jun 15;30(12):1470-80. doi: 10.1101/gad.279190.116. Genes Dev. 2016. PMID: 27340177 Free PMC article.
In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer.
Annunziato S, Lutz C, Henneman L, Bhin J, Wong K, Siteur B, van Gerwen B, de Korte-Grimmerink R, Zafra MP, Schatoff EM, Drenth AP, van der Burg E, Eijkman T, Mukherjee S, Boroviak K, Wessels LF, van de Ven M, Huijbers IJ, Adams DJ, Dow LE, Jonkers J. Annunziato S, et al. Among authors: huijbers ij. EMBO J. 2020 Mar 2;39(5):e102169. doi: 10.15252/embj.2019102169. Epub 2020 Jan 13. EMBO J. 2020. PMID: 31930530 Free PMC article.
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Loregger A, Raaben M, Nieuwenhuis J, Tan JME, Jae LT, van den Hengel LG, Hendrix S, van den Berg M, Scheij S, Song JY, Huijbers IJ, Kroese LJ, Ottenhoff R, van Weeghel M, van de Sluis B, Brummelkamp T, Zelcer N. Loregger A, et al. Among authors: huijbers ij. Nat Commun. 2020 Feb 28;11(1):1128. doi: 10.1038/s41467-020-14811-1. Nat Commun. 2020. PMID: 32111832 Free PMC article.
42 results