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Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.
McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S, Zhang B, Luus L, Overland R, Nguyen S, Gu J, Kohli N, Wallace M, Feldhaus MJ, Kudla AJ, Schoeberl B, Nielsen UB. McDonagh CF, et al. Among authors: huhalov a. Mol Cancer Ther. 2012 Mar;11(3):582-93. doi: 10.1158/1535-7163.MCT-11-0820. Epub 2012 Jan 16. Mol Cancer Ther. 2012. PMID: 22248472
Clinical applications of phage-derived sFvs and sFv fusion proteins.
Chester KA, Bhatia J, Boxer G, Cooke SP, Flynn AA, Huhalov A, Mayer A, Pedley RB, Robson L, Sharma SK, Spencer DI, Begent RH. Chester KA, et al. Among authors: huhalov a. Dis Markers. 2000;16(1-2):53-62. doi: 10.1155/2000/672706. Dis Markers. 2000. PMID: 11360829 Free PMC article. Review.
Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7.
Zhu Q, Zeng C, Huhalov A, Yao J, Turi TG, Danley D, Hynes T, Cong Y, DiMattia D, Kennedy S, Daumy G, Schaeffer E, Marasco WA, Huston JS. Zhu Q, et al. Among authors: huhalov a. J Immunol Methods. 1999 Dec 10;231(1-2):207-22. doi: 10.1016/s0022-1759(99)00158-1. J Immunol Methods. 1999. PMID: 10648939