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A general calculus of fitness landscapes finds genes under selection in cancers.
Hsu TK, Asmussen J, Koire A, Choi BK, Gadhikar MA, Huh E, Lin CH, Konecki DM, Kim YW, Pickering CR, Kimmel M, Donehower LA, Frederick MJ, Myers JN, Katsonis P, Lichtarge O. Hsu TK, et al. Among authors: huh e. Genome Res. 2022 May;32(5):916-929. doi: 10.1101/gr.275811.121. Epub 2022 Mar 17. Genome Res. 2022. PMID: 35301263 Free PMC article.
Functional variants identify sex-specific genes and pathways in Alzheimer's Disease.
Bourquard T, Lee K, Al-Ramahi I, Pham M, Shapiro D, Lagisetty Y, Soleimani S, Mota S, Wilhelm K, Samieinasab M, Kim YW, Huh E, Asmussen J, Katsonis P, Botas J, Lichtarge O. Bourquard T, et al. Among authors: huh e. Nat Commun. 2023 May 13;14(1):2765. doi: 10.1038/s41467-023-38374-z. Nat Commun. 2023. PMID: 37179358 Free PMC article.
Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.
Gao W, Liu L, Huh E, Gbahou F, Cecon E, Oshima M, Houzé L, Katsonis P, Hegron A, Fan Z, Hou G, Charpentier G, Boissel M, Derhourhi M, Marre M, Balkau B, Froguel P, Scharfmann R, Lichtarge O, Dam J, Bonnefond A, Liu J, Jockers R. Gao W, et al. Among authors: huh e. Nat Metab. 2023 Oct;5(10):1673-1684. doi: 10.1038/s42255-023-00889-6. Epub 2023 Sep 14. Nat Metab. 2023. PMID: 37709961
Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.
Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, Canouil M, Boissel M, Charpentier G, Roussel R, Balkau B, Froguel P, Plouffe B, Bonnefond A, Lichtarge O, Jockers R, Bouvier M. Hegron A, et al. Among authors: huh e. ACS Pharmacol Transl Sci. 2021 Sep 1;4(5):1614-1627. doi: 10.1021/acsptsci.1c00157. eCollection 2021 Oct 8. ACS Pharmacol Transl Sci. 2021. PMID: 34661078 Free PMC article.
112 results