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Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.
Zhao XZ, Smith SJ, Maskell DP, Métifiot M, Pye VE, Fesen K, Marchand C, Pommier Y, Cherepanov P, Hughes SH, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. J Med Chem. 2017 Sep 14;60(17):7315-7332. doi: 10.1021/acs.jmedchem.7b00596. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28737946 Free PMC article.
Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: correlation of binding energy with biological activity for novel 2-aryl-substituted benzimidazole analogues.
Kroeger Smith MB, Hose BM, Hawkins A, Lipchock J, Farnsworth DW, Rizzo RC, Tirado-Rives J, Arnold E, Zhang W, Hughes SH, Jorgensen WL, Michejda CJ, Smith RH Jr. Kroeger Smith MB, et al. Among authors: hughes sh. J Med Chem. 2003 May 8;46(10):1940-7. doi: 10.1021/jm020271f. J Med Chem. 2003. PMID: 12723956
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E. Himmel DM, et al. Among authors: hughes sh. J Med Chem. 2005 Dec 1;48(24):7582-91. doi: 10.1021/jm0500323. J Med Chem. 2005. PMID: 16302798
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme.
Morningstar ML, Roth T, Farnsworth DW, Smith MK, Watson K, Buckheit RW Jr, Das K, Zhang W, Arnold E, Julias JG, Hughes SH, Michejda CJ. Morningstar ML, et al. Among authors: hughes sh. J Med Chem. 2007 Aug 23;50(17):4003-15. doi: 10.1021/jm060103d. Epub 2007 Jul 31. J Med Chem. 2007. PMID: 17663538 Free PMC article.
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH. Boyer PL, et al. Among authors: hughes sh. J Med Chem. 2009 Sep 10;52(17):5356-64. doi: 10.1021/jm801176e. J Med Chem. 2009. PMID: 19678643 Free PMC article.
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Ferris AL, et al. Among authors: hughes cm, hughes sh. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3135-40. doi: 10.1073/pnas.0914142107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133638 Free PMC article.
385 results