Hughes SH - Search Results

1

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. Chem Biol Drug Des. 2012 Feb;79(2):157-65. doi: 10.1111/j.1747-0285.2011.01270.x. Epub 2011 Dec 22. Chem Biol Drug Des. 2012. PMID: 22107736 Free PMC article.

2

HIV-1 reverse transcriptase variants: molecular modeling of Y181C, V106A, L100I, and K103N mutations with nonnucleoside inhibitors using Monte Carlo simulations in combination with a linear response method.

Smith MB, Ruby S, Horouzhenko S, Buckingham B, Richardson J, Puleri I, Potts E, Jorgensen WL, Arnold E, Zhang W, Hughes SH, Michejda CJ, Smith RH Jr. Smith MB, et al. Among authors: hughes sh. Drug Des Discov. 2003;18(4):151-63. doi: 10.3109/10559610390484203. Drug Des Discov. 2003. PMID: 15553926

3

Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases.

Boyer PL, Julias JG, Marquez VE, Hughes SH. Boyer PL, et al. Among authors: hughes sh. J Mol Biol. 2005 Jan 21;345(3):441-50. doi: 10.1016/j.jmb.2004.10.021. J Mol Biol. 2005. PMID: 15581889

4

Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication.

Mulky A, Vu BC, Conway JA, Hughes SH, Kappes JC. Mulky A, et al. Among authors: hughes sh. J Mol Biol. 2007 Feb 2;365(5):1368-78. doi: 10.1016/j.jmb.2006.10.089. Epub 2006 Nov 10. J Mol Biol. 2007. PMID: 17141805

5

The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.

Boyer PL, Julias JG, Ambrose Z, Siddiqui MA, Marquez VE, Hughes SH. Boyer PL, et al. Among authors: hughes sh. J Mol Biol. 2007 Aug 24;371(4):873-82. doi: 10.1016/j.jmb.2007.05.043. Epub 2007 May 18. J Mol Biol. 2007. PMID: 17597154

6

2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.

Zhao XZ, Semenova EA, Vu BC, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. J Med Chem. 2008 Jan 24;51(2):251-9. doi: 10.1021/jm070715d. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095643

7

D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.

Comin MJ, Vu BC, Boyer PL, Liao C, Hughes SH, Marquez VE. Comin MJ, et al. Among authors: hughes sh. ChemMedChem. 2008 Jul;3(7):1129-34. doi: 10.1002/cmdc.200800027. ChemMedChem. 2008. PMID: 18399509 Free PMC article.

8

Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.

Saneyoshi H, Vu BC, Hughes SH, Boyer PL, Sarafianos SG, Marquez VE. Saneyoshi H, et al. Among authors: hughes sh. Nucleic Acids Symp Ser (Oxf). 2008;(52):623-4. doi: 10.1093/nass/nrn315. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776534 Free PMC article.

9

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.

Zhao XZ, Maddali K, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. Bioorg Med Chem Lett. 2009 May 15;19(10):2714-7. doi: 10.1016/j.bmcl.2009.03.122. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19364649 Free PMC article.

10

North- and south-bicyclo[3.1.0]hexene nucleosides: the effect of ring planarity on anti-HIV activity.

Russ PL, Gonzalez-Moa MJ, Vu BC, Sigano DM, Kelley JA, Lai CC, Deschamps JR, Hughes SH, Marquez VE. Russ PL, et al. Among authors: hughes sh. ChemMedChem. 2009 Aug;4(8):1354-63. doi: 10.1002/cmdc.200900153. ChemMedChem. 2009. PMID: 19533724 Free PMC article.

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