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Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency.
Hughes SA, Lin M, Weir A, Huang B, Xiong L, Chua NK, Pang J, Santavanond JP, Tixeira R, Doerflinger M, Deng Y, Yu CH, Silke N, Conos SA, Frank D, Simpson DS, Murphy JM, Lawlor KE, Pearson JS, Silke J, Pellegrini M, Herold MJ, Poon IKH, Masters SL, Li M, Tang Q, Zhang Y, Rashidi M, Geng L, Vince JE. Hughes SA, et al. EMBO J. 2023 Mar 1;42(5):e110468. doi: 10.15252/embj.2021110468. Epub 2023 Jan 17. EMBO J. 2023. PMID: 36647737 Free PMC article.
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L, Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA, Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE, Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE, Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R, Vince JE. Simpson DS, et al. Among authors: hughes s. Immunity. 2022 Mar 8;55(3):423-441.e9. doi: 10.1016/j.immuni.2022.01.003. Epub 2022 Feb 8. Immunity. 2022. PMID: 35139355 Free PMC article.
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation.
Speir M, Tye H, Gottschalk TA, Simpson DS, Djajawi TM, Deo P, Ambrose RL, Conos SA, Emery J, Abraham G, Pascoe A, Hughes SA, Weir A, Hawkins ED, Kong I, Herold MJ, Pearson JS, Lalaoui N, Naderer T, Vince JE, Lawlor KE. Speir M, et al. Among authors: hughes sa. EMBO Rep. 2023 Nov 6;24(11):e56865. doi: 10.15252/embr.202356865. Epub 2023 Oct 17. EMBO Rep. 2023. PMID: 37846472 Free PMC article.
Mothers' Experiences During the 2022 Infant Formula Shortage in Washington D.C.
Sylvetsky AC, Hughes SA, Kuttamperoor JT, Moore HR, Murphy J, Sacheck J, Smith ER. Sylvetsky AC, et al. Among authors: hughes sa. Matern Child Health J. 2024 May;28(5):873-886. doi: 10.1007/s10995-023-03860-9. Epub 2023 Dec 26. Matern Child Health J. 2024. PMID: 38147276 Free PMC article.
88 results