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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth.
Tang R, Shuldiner EG, Kelly M, Murray CW, Hebert JD, Andrejka L, Tsai MK, Hughes NW, Parker MI, Cai H, Li YC, Wahl GM, Dunbrack RL, Jackson PK, Petrov DA, Winslow MM. Tang R, et al. Among authors: hughes nw. Nat Cell Biol. 2023 Jan;25(1):159-169. doi: 10.1038/s41556-022-01049-w. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635501 Free PMC article.
A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.
Cai H, Chew SK, Li C, Tsai MK, Andrejka L, Murray CW, Hughes NW, Shuldiner EG, Ashkin EL, Tang R, Hung KL, Chen LC, Lee SYC, Yousefi M, Lin WY, Kunder CA, Cong L, McFarland CD, Petrov DA, Swanton C, Winslow MM. Cai H, et al. Among authors: hughes nw. Cancer Discov. 2021 Jul;11(7):1754-1773. doi: 10.1158/2159-8290.CD-20-1325. Epub 2021 Feb 19. Cancer Discov. 2021. PMID: 33608386 Free PMC article.
A CRISPR Landing for Genome Rewriting at Locus-Scale.
Hughes NW, Cong L. Hughes NW, et al. CRISPR J. 2021 Apr;4(2):163-166. doi: 10.1089/crispr.2021.29124.lec. CRISPR J. 2021. PMID: 33876954 Free PMC article. No abstract available.
Modeling the genomic complexity of human cancer using Cas12a mice.
Hebert JD, Xu H, Tang YJ, Ruiz PA, Detrick C, Wang J, Hughes NW, Donosa O, Andrejka L, Karmakar S, Aboiralor I, Cong L, Sage J, Petrov DA, Winslow MM. Hebert JD, et al. Among authors: hughes nw. bioRxiv [Preprint]. 2024 Mar 8:2024.03.07.583774. doi: 10.1101/2024.03.07.583774. bioRxiv. 2024. PMID: 38496463 Free PMC article. Preprint.
15 results