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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry ST, Goodwin RJA, Kinross J, Edwards J, Yuneva MO, Sumpton D, Takats Z, Campbell AD, Bunch J, Sansom OJ. Vande Voorde J, et al. Among authors: hughes m. Nat Metab. 2023 Aug;5(8):1303-1318. doi: 10.1038/s42255-023-00857-0. Epub 2023 Aug 14. Nat Metab. 2023. PMID: 37580540 Free PMC article.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium; van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Leach JDG, et al. Among authors: hughes m. Nat Commun. 2021 Jun 8;12(1):3464. doi: 10.1038/s41467-021-23717-5. Nat Commun. 2021. PMID: 34103493 Free PMC article.
New Guinea has the world's richest island flora.
Cámara-Leret R, Frodin DG, Adema F, Anderson C, Appelhans MS, Argent G, Arias Guerrero S, Ashton P, Baker WJ, Barfod AS, Barrington D, Borosova R, Bramley GLC, Briggs M, Buerki S, Cahen D, Callmander MW, Cheek M, Chen CW, Conn BJ, Coode MJE, Darbyshire I, Dawson S, Dransfield J, Drinkell C, Duyfjes B, Ebihara A, Ezedin Z, Fu LF, Gideon O, Girmansyah D, Govaerts R, Fortune-Hopkins H, Hassemer G, Hay A, Heatubun CD, Hind DJN, Hoch P, Homot P, Hovenkamp P, Hughes M, Jebb M, Jennings L, Jimbo T, Kessler M, Kiew R, Knapp S, Lamei P, Lehnert M, Lewis GP, Linder HP, Lindsay S, Low YW, Lucas E, Mancera JP, Monro AK, Moore A, Middleton DJ, Nagamasu H, Newman MF, Nic Lughadha E, Melo PHA, Ohlsen DJ, Pannell CM, Parris B, Pearce L, Penneys DS, Perrie LR, Petoe P, Poulsen AD, Prance GT, Quakenbush JP, Raes N, Rodda M, Rogers ZS, Schuiteman A, Schwartsburd P, Scotland RW, Simmons MP, Simpson DA, Stevens P, Sundue M, Testo W, Trias-Blasi A, Turner I, Utteridge T, Walsingham L, Webber BL, Wei R, Weiblen GD, Weigend M, Weston P, de Wilde W, Wilkie P, Wilmot-Dear CM, Wilson HP, Wood JRI, Zhang LB, van Welzen PC. Cámara-Leret R, et al. Among authors: hughes m. Nature. 2020 Aug;584(7822):579-583. doi: 10.1038/s41586-020-2549-5. Epub 2020 Aug 5. Nature. 2020. PMID: 32760001
Characterization of prehistoric flint mine products.
Sieveking Gde G, Craddock PT, Hughes MJ, Bush P, Ferguson J. Sieveking Gde G, et al. Among authors: hughes mj. Nature. 1970 Oct 17;228(5268):251-4. doi: 10.1038/228251a0. Nature. 1970. PMID: 16058488
Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial.
Corado KC, Chew KW, Giganti MJ, Mu Y, Fletcher CV, Currier JS, Daar ES, Wohl DA, Li JZ, Moser CB, Ritz J, Javan AC, Neytman G, Caskey M, Hughes MD, Smith DM, Eron JJ; ACTIV-2/A5401 Study Team. Corado KC, et al. Among authors: hughes md. Pathog Immun. 2024 May 6;9(1):138-155. doi: 10.20411/pai.v9i1.660. eCollection 2024. Pathog Immun. 2024. PMID: 38746756 Free PMC article.
Effectiveness of double-dose dolutegravir in people receiving rifampin-based tuberculosis treatment: an observational, cohort study of people with HIV from six countries.
Shah NS, Kityo C, Hughes MD, McCarthy C, Wallis C, Hosseinipour M, Langat D, Nyirenda M, Rassool M, Dawson R, Joseph Y, Some F, Mngqbisa R, Mukwekwerere PG, Woolley E, Godfrey C, Manabe YC, Mellors JW, Flexner C, Maartens G; ACTG A5381/Hakim Study Team. Shah NS, et al. Among authors: hughes md. Clin Infect Dis. 2024 May 13:ciae269. doi: 10.1093/cid/ciae269. Online ahead of print. Clin Infect Dis. 2024. PMID: 38739755
Vascular Endothelial Damage in COPD: Where Are We Now, Where Will We Go?
Screm G, Mondini L, Salton F, Confalonieri P, Trotta L, Barbieri M, Romallo A, Galantino A, Hughes M, Lerda S, Confalonieri M, Ruaro B. Screm G, et al. Among authors: hughes m. Diagnostics (Basel). 2024 Apr 30;14(9):950. doi: 10.3390/diagnostics14090950. Diagnostics (Basel). 2024. PMID: 38732364 Free PMC article. Review.
3,841 results