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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium; van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Leach JDG, et al. Among authors: hughes m. Nat Commun. 2021 Jun 8;12(1):3464. doi: 10.1038/s41467-021-23717-5. Nat Commun. 2021. PMID: 34103493 Free PMC article.
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry ST, Goodwin RJA, Kinross J, Edwards J, Yuneva MO, Sumpton D, Takats Z, Campbell AD, Bunch J, Sansom OJ. Vande Voorde J, et al. Among authors: hughes m. Nat Metab. 2023 Aug;5(8):1303-1318. doi: 10.1038/s42255-023-00857-0. Epub 2023 Aug 14. Nat Metab. 2023. PMID: 37580540 Free PMC article.
New Guinea has the world's richest island flora.
Cámara-Leret R, Frodin DG, Adema F, Anderson C, Appelhans MS, Argent G, Arias Guerrero S, Ashton P, Baker WJ, Barfod AS, Barrington D, Borosova R, Bramley GLC, Briggs M, Buerki S, Cahen D, Callmander MW, Cheek M, Chen CW, Conn BJ, Coode MJE, Darbyshire I, Dawson S, Dransfield J, Drinkell C, Duyfjes B, Ebihara A, Ezedin Z, Fu LF, Gideon O, Girmansyah D, Govaerts R, Fortune-Hopkins H, Hassemer G, Hay A, Heatubun CD, Hind DJN, Hoch P, Homot P, Hovenkamp P, Hughes M, Jebb M, Jennings L, Jimbo T, Kessler M, Kiew R, Knapp S, Lamei P, Lehnert M, Lewis GP, Linder HP, Lindsay S, Low YW, Lucas E, Mancera JP, Monro AK, Moore A, Middleton DJ, Nagamasu H, Newman MF, Nic Lughadha E, Melo PHA, Ohlsen DJ, Pannell CM, Parris B, Pearce L, Penneys DS, Perrie LR, Petoe P, Poulsen AD, Prance GT, Quakenbush JP, Raes N, Rodda M, Rogers ZS, Schuiteman A, Schwartsburd P, Scotland RW, Simmons MP, Simpson DA, Stevens P, Sundue M, Testo W, Trias-Blasi A, Turner I, Utteridge T, Walsingham L, Webber BL, Wei R, Weiblen GD, Weigend M, Weston P, de Wilde W, Wilkie P, Wilmot-Dear CM, Wilson HP, Wood JRI, Zhang LB, van Welzen PC. Cámara-Leret R, et al. Among authors: hughes m. Nature. 2020 Aug;584(7822):579-583. doi: 10.1038/s41586-020-2549-5. Epub 2020 Aug 5. Nature. 2020. PMID: 32760001
A geriatric game to strengthen older adult healthcare delivery and outcomes.
Jurivich DA, Van Eck RN, Wood JR, Snustad D, Holloway J, Langendoen D, Hughes M, Galynker B, Brewster S, Manocha GD. Jurivich DA, et al. Among authors: hughes m. J Am Geriatr Soc. 2024 May 8. doi: 10.1111/jgs.18942. Online ahead of print. J Am Geriatr Soc. 2024. PMID: 38720422
Characterization of treatment resistance and viral kinetics in the setting of single- versus dual-active monoclonal antibodies against SARS-CoV-2.
Choudhary MC, Deo R, Evering TH, Chew KW, Giganti MJ, Moser C, Ritz J, Regan J, Flynn JP, Crain CR, Wohl DA, Currier JS, Eron JJ, Margolis D, Zhu Q, Zhon L, Ya L, Greninger AL, Hughes MD, Smith D, Daar ES, Li JZ; ACTIV-2/A5401 Study Team. Choudhary MC, et al. Among authors: hughes md. J Infect Dis. 2024 May 8:jiae192. doi: 10.1093/infdis/jiae192. Online ahead of print. J Infect Dis. 2024. PMID: 38716969
Multicenter Evaluation of Ultra-Rapid Lispro (URLi) Insulin with Control-IQ Technology in Adults, Adolescents and Children with Type 1 Diabetes.
Levy C, Bailey R, Laffel LM, Forlenza GP, DiMeglio LA, Hughes MS, Brown S, Aleppo G, Bhargava A, Shah V, Clements MA, Kipnes MS, Bruggeman B, Daniels M, Rodriguez H, Calhoun P, Lum J, Sasson-Katchalski R, Pinsker JE, Pollom R, Beck RW. Levy C, et al. Among authors: hughes ms. Diabetes Technol Ther. 2024 May 2. doi: 10.1089/dia.2024.0048. Online ahead of print. Diabetes Technol Ther. 2024. PMID: 38696672
Inflammatory potential of diet and mortality in Australian adults.
Majidi A, Hughes MCB, Webb IK, Miura K, van der Pols JC. Majidi A, et al. Among authors: hughes mcb. Public Health Nutr. 2024 Apr 29:1-20. doi: 10.1017/S1368980024000909. Online ahead of print. Public Health Nutr. 2024. PMID: 38680071
3,834 results