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Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.
Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes LD, Koenen M, Komuczki J, Regan-Komito D, Wagage S, Hesselmann J, Thoma R, Brugger D, Christopeit T, Wang H, Point F, Hallet R, Ghosh S, Rothlin CV, Patsch C, Geering B. Wanke F, et al. Among authors: hughes ld. Cell Death Dis. 2021 May 25;12(6):538. doi: 10.1038/s41419-021-03770-0. Cell Death Dis. 2021. PMID: 34035216 Free PMC article.
Tissue-specific modifier alleles determine Mertk loss-of-function traits.
Akalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Akalu YT, et al. Among authors: hughes ld. Elife. 2022 Aug 15;11:e80530. doi: 10.7554/eLife.80530. Elife. 2022. PMID: 35969037 Free PMC article.
Death begets a new beginning.
Bosurgi L, Hughes LD, Rothlin CV, Ghosh S. Bosurgi L, et al. Among authors: hughes ld. Immunol Rev. 2017 Nov;280(1):8-25. doi: 10.1111/imr.12585. Immunol Rev. 2017. PMID: 29027219 Free PMC article. Review.
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Bosurgi L, et al. Among authors: hughes ld. Science. 2017 Jun 9;356(6342):1072-1076. doi: 10.1126/science.aai8132. Epub 2017 May 11. Science. 2017. PMID: 28495875 Free PMC article.
108 results