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Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome.
Zatyka M, Rosenstock TR, Sun C, Palhegyi AM, Hughes GW, Lara-Reyna S, Astuti D, di Maio A, Sciauvaud A, Korsgen ME, Stanulovic V, Kocak G, Rak M, Pourtoy-Brasselet S, Winter K, Varga T, Jarrige M, Polvèche H, Correia J, Frickel EM, Hoogenkamp M, Ward DG, Aubry L, Barrett T, Sarkar S. Zatyka M, et al. Among authors: hughes gw. Stem Cell Reports. 2023 May 9;18(5):1090-1106. doi: 10.1016/j.stemcr.2023.04.002. Stem Cell Reports. 2023. PMID: 37163979 Free PMC article.
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE, Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson DG, Frickel EM, Rosenstock TR, Barrett T, Maddocks ODK, Tennant DA, Wang H, Jaenisch R, Korolchuk VI, Sarkar S. Sun C, et al. Among authors: hughes gw. Cell Rep. 2023 May 30;42(5):112372. doi: 10.1016/j.celrep.2023.112372. Epub 2023 Apr 21. Cell Rep. 2023. PMID: 37086404 Free PMC article.
Surface-tethered planar membranes containing the β-barrel assembly machinery: a platform for investigating bacterial outer membrane protein folding.
Hall SCL, Clifton LA, Sridhar P, Hardy DJ, Wotherspoon P, Wright J, Whitehouse J, Gamage N, Laxton CS, Hatton C, Hughes GW, Jeeves M, Knowles TJ. Hall SCL, et al. Among authors: hughes gw. Biophys J. 2021 Dec 7;120(23):5295-5308. doi: 10.1016/j.bpj.2021.10.033. Epub 2021 Oct 30. Biophys J. 2021. PMID: 34757080 Free PMC article.
Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system.
Hughes GW, Hall SCL, Laxton CS, Sridhar P, Mahadi AH, Hatton C, Piggot TJ, Wotherspoon PJ, Leney AC, Ward DG, Jamshad M, Spana V, Cadby IT, Harding C, Isom GL, Bryant JA, Parr RJ, Yakub Y, Jeeves M, Huber D, Henderson IR, Clifton LA, Lovering AL, Knowles TJ. Hughes GW, et al. Nat Microbiol. 2019 Oct;4(10):1692-1705. doi: 10.1038/s41564-019-0481-y. Epub 2019 Jun 24. Nat Microbiol. 2019. PMID: 31235958
A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.
Fernandez-Petty CM, Hughes GW, Bowers HL, Watson JD, Rosen BH, Townsend SM, Santos C, Ridley CE, Chu KK, Birket SE, Li Y, Leung HM, Mazur M, Garcia BA, Evans TIA, Libby EF, Hathorne H, Hanes J, Tearney GJ, Clancy JP, Engelhardt JF, Swords WE, Thornton DJ, Wiesmann WP, Baker SM, Rowe SM. Fernandez-Petty CM, et al. Among authors: hughes gw. JCI Insight. 2019 Apr 18;4(8):e125954. doi: 10.1172/jci.insight.125954. eCollection 2019 Apr 18. JCI Insight. 2019. PMID: 30996141 Free PMC article.
41 results