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CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-α) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Burton LJ, Hawsawi O, Sweeney J, Bowen N, Hudson T, Odero-Marah V. Burton LJ, et al. Among authors: hudson t. PLoS One. 2019 Apr 9;14(4):e0214844. doi: 10.1371/journal.pone.0214844. eCollection 2019. PLoS One. 2019. PMID: 30964885 Free PMC article.
Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial.
Paller CJ, Zhou XC, Heath EI, Taplin ME, Mayer T, Stein MN, Bubley GJ, Pili R, Hudson T, Kakarla R, Abbas MM, Anders NM, Dowling D, King S, Bruns AB, Wagner WD, Drake CG, Antonarakis ES, Eisenberger MA, Denmeade SR, Rudek MA, Rosner GL, Carducci MA. Paller CJ, et al. Among authors: hudson t. Clin Cancer Res. 2018 Jan 15;24(2):306-315. doi: 10.1158/1078-0432.CCR-17-1100. Epub 2017 Nov 7. Clin Cancer Res. 2018. PMID: 29113986 Free PMC article. Clinical Trial.
Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.
Ignacio DN, Mason KD, Hackett-Morton EC, Albanese C, Ringer L, Wagner WD, Wang PC, Carducci MA, Kachhap SK, Paller CJ, Mendonca J, Li-Ying Chan L, Lin B, Hartle DK, Green JE, Brown CA, Hudson TS. Ignacio DN, et al. Heliyon. 2019 Jan 16;5(1):e01128. doi: 10.1016/j.heliyon.2019.e01128. eCollection 2019 Jan. Heliyon. 2019. PMID: 30705983 Free PMC article.
A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination.
Paller CJ, Rudek MA, Zhou XC, Wagner WD, Hudson TS, Anders N, Hammers HJ, Dowling D, King S, Antonarakis ES, Drake CG, Eisenberger MA, Denmeade SR, Rosner GL, Carducci MA. Paller CJ, et al. Prostate. 2015 Oct;75(14):1518-25. doi: 10.1002/pros.23024. Epub 2015 May 27. Prostate. 2015. PMID: 26012728 Free PMC article. Clinical Trial.
1,145 results