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Drug Repurposing from an Academic Perspective.
Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, Simons PC, Smagley Y, Strouse J, Surviladze Z, Thompson T, Ursu O, Waller A, Wandinger-Ness A, Winter SS, Wu Y, Young SM, Larson RS, Willman C, Sklar LA. Oprea TI, et al. Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69. doi: 10.1016/j.ddstr.2011.10.002. Drug Discov Today Ther Strateg. 2011. PMID: 22368688 Free PMC article.
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.
Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, Golden JE, Aubé J, Hudson LG, Buranda T, Sklar LA, Wandinger-Ness A. Hong L, et al. Among authors: hudson lg. J Biol Chem. 2013 Mar 22;288(12):8531-8543. doi: 10.1074/jbc.M112.435941. Epub 2013 Feb 4. J Biol Chem. 2013. PMID: 23382385 Free PMC article.
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
Guo Y, Kenney SR, Cook L, Adams SF, Rutledge T, Romero E, Oprea TI, Sklar LA, Bedrick E, Wiggins CL, Kang H, Lomo L, Muller CY, Wandinger-Ness A, Hudson LG. Guo Y, et al. Among authors: hudson lg. Clin Cancer Res. 2015 Nov 15;21(22):5064-72. doi: 10.1158/1078-0432.CCR-15-0461. Epub 2015 Jun 12. Clin Cancer Res. 2015. PMID: 26071482 Free PMC article. Clinical Trial.
Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.
Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A. Oprea TI, et al. Among authors: hudson lg. PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015. PLoS One. 2015. PMID: 26558612 Free PMC article.
Dual Actions of Ketorolac in Metastatic Ovarian Cancer.
Hudson LG, Cook LS, Grimes MM, Muller CY, Adams SF, Wandinger-Ness A. Hudson LG, et al. Cancers (Basel). 2019 Jul 24;11(8):1049. doi: 10.3390/cancers11081049. Cancers (Basel). 2019. PMID: 31344967 Free PMC article. Review.
132 results