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Leveraging base-pair mammalian constraint to understand genetic variation and human disease.
Sullivan PF, Meadows JRS, Gazal S, Phan BN, Li X, Genereux DP, Dong MX, Bianchi M, Andrews G, Sakthikumar S, Nordin J, Roy A, Christmas MJ, Marinescu VD, Wang C, Wallerman O, Xue J, Yao S, Sun Q, Szatkiewicz J, Wen J, Huckins LM, Lawler A, Keough KC, Zheng Z, Zeng J, Wray NR, Li Y, Johnson J, Chen J; Zoonomia Consortium§; Paten B, Reilly SK, Hughes GM, Weng Z, Pollard KS, Pfenning AR, Forsberg-Nilsson K, Karlsson EK, Lindblad-Toh K. Sullivan PF, et al. Among authors: huckins lm. Science. 2023 Apr 28;380(6643):eabn2937. doi: 10.1126/science.abn2937. Epub 2023 Apr 28. Science. 2023. PMID: 37104612 Free PMC article.
Common genetic variation impacts stress response in the brain.
Seah C, Signer R, Deans M, Bader H, Rusielewicz T, Hicks EM, Young H, Cote A, Townsley K, Xu C, Hunter CJ, McCarthy B, Goldberg J, Dobariya S, Holtzherimer PE, Young KA; NYSCF Global Stem Cell Array® Team; Traumatic Stress Brain Research Group; Noggle SA, Krystal JH, Paull D, Girgenti MJ, Yehuda R, Brennand KJ, Huckins LM. Seah C, et al. Among authors: huckins lm. bioRxiv [Preprint]. 2023 Dec 28:2023.12.27.573459. doi: 10.1101/2023.12.27.573459. bioRxiv. 2023. PMID: 38234801 Free PMC article. Preprint.
Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae.
Thompson RC, Simons NW, Wilkins L, Cheng E, Del Valle DM, Hoffman GE, Fennessy B, Mouskas K, Francoeur NJ, Johnson JS, Lepow L, Le Berichel J, Chang C, Beckmann AG, Wang YC, Nie K, Zaki N, Tuballes K, Barcessat V, Cedillo MA, Huckins L, Roussos P, Marron TU; Mount Sinai COVID-19 Biobank Team; Glicksberg BS, Nadkarni G, Gonzalez-Kozlova E, Kim-Schulze S, Sebra R, Merad M, Gnjatic S, Schadt EE, Charney AW, Beckmann ND. Thompson RC, et al. medRxiv [Preprint]. 2021 Oct 5:2021.10.04.21264434. doi: 10.1101/2021.10.04.21264434. medRxiv. 2021. PMID: 34642700 Free PMC article. Preprint.
Predictive Approaches for Acute Dialysis Requirement and Death in COVID-19.
Vaid A, Chan L, Chaudhary K, Jaladanki SK, Paranjpe I, Russak A, Kia A, Timsina P, Levin MA, He JC, Böttinger EP, Charney AW, Fayad ZA, Coca SG, Glicksberg BS, Nadkarni GN; MSCIC. Vaid A, et al. Clin J Am Soc Nephrol. 2021 Aug;16(8):1158-1168. doi: 10.2215/CJN.17311120. Epub 2021 May 24. Clin J Am Soc Nephrol. 2021. PMID: 34031183 Free PMC article.
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.
de Jong S, Diniz MJA, Saloma A, Gadelha A, Santoro ML, Ota VK, Noto C; Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium; Curtis C, Newhouse SJ, Patel H, Hall LS, O Reilly PF, Belangero SI, Bressan RA, Breen G. de Jong S, et al. Commun Biol. 2018 Oct 8;1:163. doi: 10.1038/s42003-018-0155-y. eCollection 2018. Commun Biol. 2018. PMID: 30320231 Free PMC article.
Outcomes of Patients on Maintenance Dialysis Hospitalized with COVID-19.
Chan L, Jaladanki SK, Somani S, Paranjpe I, Kumar A, Zhao S, Kaufman L, Leisman S, Sharma S, He JC, Murphy B, Fayad ZA, Levin MA, Bottinger EP, Charney AW, Glicksberg BS, Coca SG, Nadkarni GN; Mount Sinai COVID Informatics Center (MSCIC). Chan L, et al. Clin J Am Soc Nephrol. 2021 Mar 8;16(3):452-455. doi: 10.2215/CJN.12360720. Epub 2020 Oct 30. Clin J Am Soc Nephrol. 2021. PMID: 33127607 Free PMC article. No abstract available.
Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City.
Paranjpe I, Russak AJ, De Freitas JK, Lala A, Miotto R, Vaid A, Johnson KW, Danieletto M, Golden E, Meyer D, Singh M, Somani S, Kapoor A, O'Hagan R, Manna S, Nangia U, Jaladanki SK, O'Reilly P, Huckins LM, Glowe P, Kia A, Timsina P, Freeman RM, Levin MA, Jhang J, Firpo A, Kovatch P, Finkelstein J, Aberg JA, Bagiella E, Horowitz CR, Murphy B, Fayad ZA, Narula J, Nestler EJ, Fuster V, Cordon-Cardo C, Charney D, Reich DL, Just A, Bottinger EP, Charney AW, Glicksberg BS, Nadkarni GN; Mount Sinai COVID Informatics Center (MSCIC). Paranjpe I, et al. Among authors: huckins lm. BMJ Open. 2020 Nov 27;10(11):e040736. doi: 10.1136/bmjopen-2020-040736. BMJ Open. 2020. PMID: 33247020 Free PMC article.
Machine Learning to Predict Mortality and Critical Events in a Cohort of Patients With COVID-19 in New York City: Model Development and Validation.
Vaid A, Somani S, Russak AJ, De Freitas JK, Chaudhry FF, Paranjpe I, Johnson KW, Lee SJ, Miotto R, Richter F, Zhao S, Beckmann ND, Naik N, Kia A, Timsina P, Lala A, Paranjpe M, Golden E, Danieletto M, Singh M, Meyer D, O'Reilly PF, Huckins L, Kovatch P, Finkelstein J, Freeman RM, Argulian E, Kasarskis A, Percha B, Aberg JA, Bagiella E, Horowitz CR, Murphy B, Nestler EJ, Schadt EE, Cho JH, Cordon-Cardo C, Fuster V, Charney DS, Reich DL, Bottinger EP, Levin MA, Narula J, Fayad ZA, Just AC, Charney AW, Nadkarni GN, Glicksberg BS. Vaid A, et al. J Med Internet Res. 2020 Nov 6;22(11):e24018. doi: 10.2196/24018. J Med Internet Res. 2020. PMID: 33027032 Free PMC article.
81 results