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Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H. Barker N, et al. Among authors: huch m. Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013. Cell Stem Cell. 2010. PMID: 20085740 Free article.
Stem cells and cancer of the stomach and intestine.
Vries RG, Huch M, Clevers H. Vries RG, et al. Among authors: huch m. Mol Oncol. 2010 Oct;4(5):373-84. doi: 10.1016/j.molonc.2010.05.001. Epub 2010 Jun 8. Mol Oncol. 2010. PMID: 20598659 Free PMC article. Review.
Sox9 marks adult organ progenitors.
Huch M, Clevers H. Huch M, et al. Nat Genet. 2011 Jan;43(1):9-10. doi: 10.1038/ng0111-9. Nat Genet. 2011. PMID: 21217637 No abstract available.
Controlled gene expression in primary Lgr5 organoid cultures.
Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H. Koo BK, et al. Among authors: huch m. Nat Methods. 2011 Dec 4;9(1):81-3. doi: 10.1038/nmeth.1802. Nat Methods. 2011. PMID: 22138822
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H. Barker N, et al. Among authors: huch m. Cell Rep. 2012 Sep 27;2(3):540-52. doi: 10.1016/j.celrep.2012.08.018. Epub 2012 Sep 20. Cell Rep. 2012. PMID: 22999937 Free article.
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H. Huch M, et al. EMBO J. 2013 Oct 16;32(20):2708-21. doi: 10.1038/emboj.2013.204. Epub 2013 Sep 17. EMBO J. 2013. PMID: 24045232 Free PMC article.
149 results