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Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.
Diabetologia. 2023 Mar;66(3):567-578. doi: 10.1007/s00125-022-05838-8. Epub 2022 Dec 1.
Diabetologia. 2023.
PMID: 36456864
Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, Gaspar RC, Zhang XM, Cline GW, Nakahara K, Woo S, Shimada A, Hüttemann M, Shulman GI.
LaMoia TE, et al. Among authors: hubbard bt.
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2122287119. doi: 10.1073/pnas.2122287119. Epub 2022 Mar 1.
Proc Natl Acad Sci U S A. 2022.
PMID: 35238637
Free PMC article.
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Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo.
Hubbard BT, LaMoia TE, Goedeke L, Gaspar RC, Galsgaard KD, Kahn M, Mason GF, Shulman GI.
Hubbard BT, et al.
Cell Metab. 2023 Jan 3;35(1):212-226.e4. doi: 10.1016/j.cmet.2022.11.011. Epub 2022 Dec 13.
Cell Metab. 2023.
PMID: 36516861
Free PMC article.
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MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis.
Park J, Hall C, Hubbard B, LaMoia T, Gaspar R, Nasiri A, Li F, Zhang H, Kim J, Haeusler RA, Accili D, Shulman GI, Yu H, Choi E.
Park J, et al.
Diabetes. 2023 Dec 1;72(12):1781-1794. doi: 10.2337/db23-0314.
Diabetes. 2023.
PMID: 37725942
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Systemic gene therapy for methylmalonic acidemia using the novel adeno-associated viral vector 44.9.
Chandler RJ, Di Pasquale G, Sloan JL, McCoy S, Hubbard BT, Kilts TM, Manoli I, Chiorini JA, Venditti CP.
Chandler RJ, et al. Among authors: hubbard bt.
Mol Ther Methods Clin Dev. 2022 Sep 6;27:61-72. doi: 10.1016/j.omtm.2022.09.001. eCollection 2022 Dec 8.
Mol Ther Methods Clin Dev. 2022.
PMID: 36186952
Free PMC article.
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Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia.
Chandler RJ, Venturoni LE, Liao J, Hubbard BT, Schneller JL, Hoffmann V, Gordo S, Zang S, Ko CW, Chau N, Chiang K, Kay MA, Barzel A, Venditti CP.
Chandler RJ, et al. Among authors: hubbard bt.
Hepatology. 2021 Jun;73(6):2223-2237. doi: 10.1002/hep.31570. Epub 2021 May 21.
Hepatology. 2021.
PMID: 32976669
Free PMC article.
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Systemic AAV9 gene therapy improves the lifespan of mice with Niemann-Pick disease, type C1.
Chandler RJ, Williams IM, Gibson AL, Davidson CD, Incao AA, Hubbard BT, Porter FD, Pavan WJ, Venditti CP.
Chandler RJ, et al. Among authors: hubbard bt.
Hum Mol Genet. 2017 Jan 1;26(1):52-64. doi: 10.1093/hmg/ddw367.
Hum Mol Genet. 2017.
PMID: 27798114
Free PMC article.
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