Huang Y - Search Results

1

Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease.

Taubes A, Nova P, Zalocusky KA, Kosti I, Bicak M, Zilberter MY, Hao Y, Yoon SY, Oskotsky T, Pineda S, Chen B, Jones EAA, Choudhary K, Grone B, Balestra ME, Chaudhry F, Paranjpe I, De Freitas J, Koutsodendris N, Chen N, Wang C, Chang W, An A, Glicksberg BS, Sirota M, Huang Y. Taubes A, et al. Among authors: huang y. Nat Aging. 2021 Oct;1(10):932-947. doi: 10.1038/s43587-021-00122-7. Epub 2021 Oct 11. Nat Aging. 2021. PMID: 36172600 Free PMC article.

2

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. Chang S, et al. Among authors: huang y. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18694-9. doi: 10.1073/pnas.0508254102. Epub 2005 Dec 12. Proc Natl Acad Sci U S A. 2005. PMID: 16344479 Free PMC article.

3

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. Brodbeck J, et al. Among authors: huang y. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1343-6. doi: 10.1073/pnas.0709906104. Epub 2008 Jan 22. Proc Natl Acad Sci U S A. 2008. PMID: 18212130 Free PMC article.

4

Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.

Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y. Xu Q, et al. Among authors: huang y. J Neurosci. 2008 Feb 6;28(6):1452-9. doi: 10.1523/JNEUROSCI.3253-07.2008. J Neurosci. 2008. PMID: 18256266 Free PMC article.

5

Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Andrews-Zwilling Y, et al. Among authors: huang y. J Neurosci. 2010 Oct 13;30(41):13707-17. doi: 10.1523/JNEUROSCI.4040-10.2010. J Neurosci. 2010. PMID: 20943911 Free PMC article.

6

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.

Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Brodbeck J, et al. Among authors: huang y. J Biol Chem. 2011 May 13;286(19):17217-26. doi: 10.1074/jbc.M110.217380. Epub 2011 Mar 18. J Biol Chem. 2011. PMID: 21454574 Free PMC article.

7

Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Chen HK, et al. Among authors: huang y. J Biol Chem. 2012 Feb 17;287(8):5253-66. doi: 10.1074/jbc.M111.276162. Epub 2011 Dec 12. J Biol Chem. 2012. PMID: 22158868 Free PMC article.

8

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.

Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. Bien-Ly N, et al. Among authors: huang y. J Neurosci. 2012 Apr 4;32(14):4803-11. doi: 10.1523/JNEUROSCI.0033-12.2012. J Neurosci. 2012. PMID: 22492035 Free PMC article.

9

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. Ring KL, et al. Among authors: huang y. Cell Stem Cell. 2012 Jul 6;11(1):100-9. doi: 10.1016/j.stem.2012.05.018. Epub 2012 Jun 7. Cell Stem Cell. 2012. PMID: 22683203 Free PMC article.

10

Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.

Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. Andrews-Zwilling Y, et al. Among authors: huang y. PLoS One. 2012;7(7):e40555. doi: 10.1371/journal.pone.0040555. Epub 2012 Jul 5. PLoS One. 2012. PMID: 22792368 Free PMC article.

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