Huang XP - Search Results

1

Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels.

Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC. Twiner MJ, et al. Among authors: huang xp. Chem Res Toxicol. 2012 Sep 17;25(9):1975-84. doi: 10.1021/tx300283t. Epub 2012 Aug 10. Chem Res Toxicol. 2012. PMID: 22856456 Free PMC article.

2

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: huang xp. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

3

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo.

Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL. Abbas AI, et al. Among authors: huang xp. Psychopharmacology (Berl). 2009 Jul;205(1):119-28. doi: 10.1007/s00213-009-1521-8. Epub 2009 Apr 1. Psychopharmacology (Berl). 2009. PMID: 19337725 Free PMC article.

4

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. Kwon YJ, et al. Among authors: huang xp. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5488-90. doi: 10.1016/j.bmcl.2010.07.074. Epub 2010 Jul 21. Bioorg Med Chem Lett. 2010. PMID: 20692833

5

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Hajjo R, et al. Among authors: huang xp. J Med Chem. 2010 Nov 11;53(21):7573-86. doi: 10.1021/jm100600y. J Med Chem. 2010. PMID: 20958049 Free PMC article.

6

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL. Huang XP, et al. Assay Drug Dev Technol. 2010 Dec;8(6):727-42. doi: 10.1089/adt.2010.0331. Assay Drug Dev Technol. 2010. PMID: 21158687 Free PMC article.

7

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J. Vedadi M, et al. Among authors: huang xp. Nat Chem Biol. 2011 Jul 10;7(8):566-74. doi: 10.1038/nchembio.599. Nat Chem Biol. 2011. PMID: 21743462 Free PMC article.

8

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.

Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. Thompson AA, et al. Among authors: huang xp. Nature. 2012 May 16;485(7398):395-9. doi: 10.1038/nature11085. Nature. 2012. PMID: 22596163 Free PMC article.

9

Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.

Lin X, Huang XP, Chen G, Whaley R, Peng S, Wang Y, Zhang G, Wang SX, Wang S, Roth BL, Huang N. Lin X, et al. Among authors: huang n, huang xp. J Med Chem. 2012 Jun 28;55(12):5749-59. doi: 10.1021/jm300338m. Epub 2012 Jun 19. J Med Chem. 2012. PMID: 22694093 Free PMC article.

10

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family.

Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE. Pigott A, et al. Among authors: huang xp. Beilstein J Org Chem. 2012;8:1705-9. doi: 10.3762/bjoc.8.194. Epub 2012 Oct 8. Beilstein J Org Chem. 2012. PMID: 23209503 Free PMC article.

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