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A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.
Jang JY, Hwang I, Pan H, Yao J, Alinari L, Imada E, Zanettini C, Kluk MJ, Wang Y, Lee Y, Lin HV, Huang X, Di Liberto M, Chen Z, Ballman KV, Cantley LC, Marchionni L, Inghirami G, Elemento O, Baiocchi RA, Chen-Kiang S, Belvedere S, Zheng H, Paik J. Jang JY, et al. Among authors: huang x. J Clin Invest. 2022 Dec 15;132(24):e160767. doi: 10.1172/JCI160767. J Clin Invest. 2022. PMID: 36282572 Free PMC article.
MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.
Nardiello T, Jungbluth AA, Mei A, Diliberto M, Huang X, Dabrowski A, Andrade VC, Wasserstrum R, Ely S, Niesvizky R, Pearse R, Coleman M, Jayabalan DS, Bhardwaj N, Old LJ, Chen-Kiang S, Cho HJ. Nardiello T, et al. Among authors: huang x. Clin Cancer Res. 2011 Jul 1;17(13):4309-19. doi: 10.1158/1078-0432.CCR-10-1820. Epub 2011 May 12. Clin Cancer Res. 2011. PMID: 21565982 Free PMC article.
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S. Huang X, et al. Blood. 2012 Aug 2;120(5):1095-106. doi: 10.1182/blood-2012-03-415984. Epub 2012 Jun 20. Blood. 2012. PMID: 22718837 Free PMC article.
Targeting CDK4/6 in mantle cell lymphoma.
Lee C, Huang X, Di Liberto M, Martin P, Chen-Kiang S. Lee C, et al. Among authors: huang x. Ann Lymphoma. 2020 Mar;4:1. doi: 10.21037/aol.2019.12.01. Ann Lymphoma. 2020. PMID: 32783046 Free PMC article.
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