Huang X - Search Results

1

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.

Starcher CL, Pay SL, Singh N, Yeh IJ, Bhandare SB, Su X, Huang X, Bey EA, Motea EA, Boothman DA. Starcher CL, et al. Among authors: huang x. Front Oncol. 2020 Aug 19;10:1575. doi: 10.3389/fonc.2020.01575. eCollection 2020. Front Oncol. 2020. PMID: 32974194 Free PMC article. Review.

2

An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.

Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA. Huang X, et al. Cancer Res. 2012 Jun 15;72(12):3038-47. doi: 10.1158/0008-5472.CAN-11-3135. Epub 2012 Apr 24. Cancer Res. 2012. PMID: 22532167 Free PMC article.

3

Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.

Ma X, Huang X, Huang G, Li L, Wang Y, Luo X, Boothman DA, Gao J. Ma X, et al. Among authors: huang x, huang g. Adv Healthc Mater. 2014 Aug;3(8):1210-6. doi: 10.1002/adhm.201300590. Epub 2014 Feb 14. Adv Healthc Mater. 2014. PMID: 24532286 Free PMC article.

4

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.

Ma X, Huang X, Moore Z, Huang G, Kilgore JA, Wang Y, Hammer S, Williams NS, Boothman DA, Gao J. Ma X, et al. Among authors: huang x, huang g. J Control Release. 2015 Feb 28;200:201-11. doi: 10.1016/j.jconrel.2014.12.027. Epub 2014 Dec 24. J Control Release. 2015. PMID: 25542645 Free PMC article.

5

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.

Huang X, Motea EA, Moore ZR, Yao J, Dong Y, Chakrabarti G, Kilgore JA, Silvers MA, Patidar PL, Cholka A, Fattah F, Cha Y, Anderson GG, Kusko R, Peyton M, Yan J, Xie XJ, Sarode V, Williams NS, Minna JD, Beg M, Gerber DE, Bey EA, Boothman DA. Huang X, et al. Cancer Cell. 2016 Dec 12;30(6):940-952. doi: 10.1016/j.ccell.2016.11.006. Cancer Cell. 2016. PMID: 27960087 Free PMC article.

6

Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.

Beg MS, Huang X, Silvers MA, Gerber DE, Bolluyt J, Sarode V, Fattah F, Deberardinis RJ, Merritt ME, Xie XJ, Leff R, Laheru D, Boothman DA. Beg MS, et al. Among authors: huang x. J Surg Oncol. 2017 Jul;116(1):83-88. doi: 10.1002/jso.24624. Epub 2017 Mar 27. J Surg Oncol. 2017. PMID: 28346693 Free PMC article.

7

Modulators of Redox Metabolism in Head and Neck Cancer.

Chen X, Mims J, Huang X, Singh N, Motea E, Planchon SM, Beg M, Tsang AW, Porosnicu M, Kemp ML, Boothman DA, Furdui CM. Chen X, et al. Among authors: huang x. Antioxid Redox Signal. 2018 Dec 1;29(16):1660-1690. doi: 10.1089/ars.2017.7423. Epub 2017 Dec 20. Antioxid Redox Signal. 2018. PMID: 29113454 Free PMC article. Review.

8

NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers.

Motea EA, Huang X, Singh N, Kilgore JA, Williams NS, Xie XJ, Gerber DE, Beg MS, Bey EA, Boothman DA. Motea EA, et al. Among authors: huang x. Clin Cancer Res. 2019 Apr 15;25(8):2601-2609. doi: 10.1158/1078-0432.CCR-18-2560. Epub 2019 Jan 7. Clin Cancer Res. 2019. PMID: 30617135 Free PMC article.

9

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance.

Li X, Liu Z, Zhang A, Han C, Shen A, Jiang L, Boothman DA, Qiao J, Wang Y, Huang X, Fu YX. Li X, et al. Among authors: huang x. Nat Commun. 2019 Jul 19;10(1):3251. doi: 10.1038/s41467-019-11238-1. Nat Commun. 2019. PMID: 31324798 Free PMC article.

10

PCNA inhibition enhances the cytotoxicity of β-lapachone in NQO1-Positive cancer cells by augmentation of oxidative stress-induced DNA damage.

Su X, Wang J, Jiang L, Chen Y, Lu T, Mendonca MS, Huang X. Su X, et al. Among authors: huang x. Cancer Lett. 2021 Oct 28;519:304-314. doi: 10.1016/j.canlet.2021.07.040. Epub 2021 Jul 27. Cancer Lett. 2021. PMID: 34329742 Free PMC article.

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