Huang T - Search Results

1

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects.

Busey GW, Manjegowda MC, Huang T, Iobst WH, Naphade SS, Kennedy JA, Doyle CA, Seegren PV, Lynch KR, Desai BN. Busey GW, et al. Among authors: huang t. J Gen Physiol. 2024 Jan 1;156(1):e202313419. doi: 10.1085/jgp.202313419. Epub 2023 Nov 9. J Gen Physiol. 2024. PMID: 37943249 Free PMC article.

2

Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.

Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Kennedy PC, et al. Among authors: huang t. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. doi: 10.1124/jpet.111.181552. Epub 2011 Jun 1. J Pharmacol Exp Ther. 2011. PMID: 21632869 Free PMC article.

3

Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors.

Kharel Y, Huang T, Santos WL, Lynch KR. Kharel Y, et al. Among authors: huang t. SLAS Discov. 2023 Sep;28(6):284-287. doi: 10.1016/j.slasd.2023.07.001. Epub 2023 Jul 16. SLAS Discov. 2023. PMID: 37454972 Free article.

4

Mechanism of sphingosine 1-phosphate clearance from blood.

Kharel Y, Huang T, Salamon A, Harris TE, Santos WL, Lynch KR. Kharel Y, et al. Among authors: huang t. Biochem J. 2020 Mar 13;477(5):925-935. doi: 10.1042/BCJ20190730. Biochem J. 2020. PMID: 32065229 Free PMC article.

5

Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors.

Shrader CW, Foster D, Kharel Y, Huang T, Lynch KR, Santos WL. Shrader CW, et al. Among authors: huang t. Bioorg Med Chem Lett. 2023 Nov 15;96:129516. doi: 10.1016/j.bmcl.2023.129516. Epub 2023 Oct 11. Bioorg Med Chem Lett. 2023. PMID: 37832799

6

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.

Sibley CD, Morris EA, Kharel Y, Brown AM, Huang T, Bevan DR, Lynch KR, Santos WL. Sibley CD, et al. Among authors: huang t. J Med Chem. 2020 Feb 13;63(3):1178-1198. doi: 10.1021/acs.jmedchem.9b01508. Epub 2020 Jan 28. J Med Chem. 2020. PMID: 31895563 Free PMC article.

7

Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors.

Li H, Sibley CD, Kharel Y, Huang T, Brown AM, Wonilowicz LG, Bevan DR, Lynch KR, Santos WL. Li H, et al. Among authors: huang t. Bioorg Med Chem. 2021 Jan 15;30:115941. doi: 10.1016/j.bmc.2020.115941. Epub 2020 Dec 13. Bioorg Med Chem. 2021. PMID: 33385956 Free PMC article.

8

Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.

Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WL. Fritzemeier R, et al. Among authors: huang t. J Med Chem. 2022 Jun 9;65(11):7656-7681. doi: 10.1021/acs.jmedchem.1c02171. Epub 2022 May 24. J Med Chem. 2022. PMID: 35609189 Free PMC article.

9

2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2).

Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. Burgio AL, et al. Among authors: huang t. J Med Chem. 2023 Apr 27;66(8):5873-5891. doi: 10.1021/acs.jmedchem.3c00149. Epub 2023 Apr 3. J Med Chem. 2023. PMID: 37010497 Free PMC article.

10

Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney.

Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, Rosin DL, Schwab SR, Santos WL, Lynch KR, Okusa MD. Tanaka S, et al. Among authors: huang t. Sci Transl Med. 2022 Aug 17;14(658):eabj2681. doi: 10.1126/scitranslmed.abj2681. Epub 2022 Aug 17. Sci Transl Med. 2022. PMID: 35976996 Free PMC article.

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