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The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
Huang LS, Mathew B, Li H, Zhao Y, Ma SF, Noth I, Reddy SP, Harijith A, Usatyuk PV, Berdyshev EV, Kaminski N, Zhou T, Zhang W, Zhang Y, Rehman J, Kotha SR, Gurney TO, Parinandi NL, Lussier YA, Garcia JG, Natarajan V. Huang LS, et al. Am J Respir Crit Care Med. 2014 Jun 1;189(11):1402-15. doi: 10.1164/rccm.201310-1917OC. Am J Respir Crit Care Med. 2014. PMID: 24779708 Free PMC article.
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury.
Zhou B, Magana L, Hong Z, Huang LS, Chakraborty S, Tsukasaki Y, Huang C, Wang L, Di A, Ganesh B, Gao X, Rehman J, Malik AB. Zhou B, et al. Among authors: huang c, huang ls. Nat Immunol. 2020 Nov;21(11):1430-1443. doi: 10.1038/s41590-020-0764-8. Epub 2020 Aug 24. Nat Immunol. 2020. PMID: 32839607 Free PMC article.
The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Cheresh P, Kim SJ, Huang LS, Watanabe S, Joshi N, Williams KJN, Chi M, Lu Z, Harijith A, Yeldandi A, Lam AP, Gottardi C, Misharin AV, Budinger GRS, Natarajan V, Kamp DW. Cheresh P, et al. Among authors: huang ls. Int J Mol Sci. 2020 Aug 5;21(16):5595. doi: 10.3390/ijms21165595. Int J Mol Sci. 2020. PMID: 32764262 Free PMC article.
Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
Chen J, Lockett A, Zhao S, Huang LS, Wang Y, Wu W, Tang M, Haider S, Velez Rendon D, Khan R, Liu B, Felesena N, Sysol JR, Valdez-Jasso D, Tang H, Bai Y, Natarajan V, Machado RF. Chen J, et al. Among authors: huang ls. Int J Mol Sci. 2022 Nov 22;23(23):14516. doi: 10.3390/ijms232314516. Int J Mol Sci. 2022. PMID: 36498853 Free PMC article.
434 results