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Design and synthesis of 4-anilinoquinazolines as Raf kinase inhibitors. Part 1. Selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 inhibitory 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines.
Lee CI, Liao CB, Chen CS, Cheng FY, Chung YH, Wang YC, Ciou SY, Hsueh WY, Lo TH, Huang GR, Huang HY, Tsai CS, Lu YJ, Chuang SH, Huang JJ. Lee CI, et al. Among authors: huang hy, huang jj, huang gr. Bioorg Chem. 2021 Apr;109:104715. doi: 10.1016/j.bioorg.2021.104715. Epub 2021 Feb 8. Bioorg Chem. 2021. PMID: 33647741
Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5α-reductase inhibitors.
Lin SF, Lin YH, Lin M, Kao YF, Wang RW, Teng LW, Chuang SH, Chang JM, Yuan TT, Fu KC, Huang KP, Lee YS, Chiang CC, Yang SC, Lai CL, Liao CB, Chen P, Lin YS, Lai KT, Huang HJ, Yang JY, Liu CW, Wei WY, Chen CK, Hiipakka RA, Liao S, Huang JJ. Lin SF, et al. Among authors: huang hj, huang jj, huang kp. Eur J Med Chem. 2010 Dec;45(12):6068-76. doi: 10.1016/j.ejmech.2010.10.011. Epub 2010 Oct 15. Eur J Med Chem. 2010. PMID: 21044810
Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties.
Lee YS, Chuang SH, Huang LY, Lai CL, Lin YH, Yang JY, Liu CW, Yang SC, Lin HS, Chang CC, Lai JY, Jian PS, Lam K, Chang JM, Lau JY, Huang JJ. Lee YS, et al. Among authors: huang jj, huang ly. J Med Chem. 2014 May 22;57(10):4098-110. doi: 10.1021/jm401990s. Epub 2014 May 7. J Med Chem. 2014. PMID: 24773549
Synthesis and antiproliferative activities of ottelione a analogues.
Chang TY, Tu YP, Wei WY, Chen HY, Chen CS, Lee YS, Huang JJ, Sha CK. Chang TY, et al. Among authors: huang jj. ACS Med Chem Lett. 2012 Oct 30;3(12):1075-80. doi: 10.1021/ml300283f. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900431 Free PMC article.
Inhibition of Hec1 as a novel approach for treatment of primary liver cancer.
Huang LY, Chang CC, Lee YS, Huang JJ, Chuang SH, Chang JM, Kao KJ, Lau GM, Tsai PY, Liu CW, Lin HS, Gish RG, Lau JY. Huang LY, et al. Among authors: huang jj. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20. doi: 10.1007/s00280-014-2540-7. Epub 2014 Jul 20. Cancer Chemother Pharmacol. 2014. PMID: 25038613
Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.
Chuang SH, Lee YE, Huang LYL, Chen CK, Lai CL, Lin YH, Yang JY, Yang SC, Chang LH, Chen CH, Liu CW, Lin HS, Lee YR, Huang KP, Fu KC, Jen HM, Lai JY, Jian PS, Wang YC, Hsueh WY, Tsai PY, Hong WH, Chang CC, Wu DZ, Wu J, Chen MH, Yu KM, Chern CY, Chang JM, Lau JYN, Huang JJ. Chuang SH, et al. Among authors: huang jj, huang kp, huang lyl. Eur J Med Chem. 2020 Apr 1;191:112118. doi: 10.1016/j.ejmech.2020.112118. Epub 2020 Feb 7. Eur J Med Chem. 2020. PMID: 32113126
1,202 results