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Defective transcription elongation in a subset of cancers confers immunotherapy resistance.
Modur V, Singh N, Mohanty V, Chung E, Muhammad B, Choi K, Chen X, Chetal K, Ratner N, Salomonis N, Weirauch MT, Waltz S, Huang G, Privette-Vinnedge L, Park JS, Janssen EM, Komurov K. Modur V, et al. Among authors: huang g. Nat Commun. 2018 Oct 23;9(1):4410. doi: 10.1038/s41467-018-06810-0. Nat Commun. 2018. PMID: 30353012 Free PMC article.
Runx1: a new driver in neurofibromagenesis.
Wu J, Huang G, Ratner N. Wu J, et al. Among authors: huang g. Oncoscience. 2015 Nov 17;2(11):904-5. doi: 10.18632/oncoscience.266. eCollection 2015. Oncoscience. 2015. PMID: 26697518 Free PMC article. No abstract available.
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Hayashi Y, et al. Among authors: huang r, huang t, huang g. Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23. Cancer Discov. 2018. PMID: 30139811 Free PMC article.
RUNX represses Pmp22 to drive neurofibromagenesis.
Hall A, Choi K, Liu W, Rose J, Zhao C, Yu Y, Na Y, Cai Y, Coover RA, Lin Y, Dombi E, Kim M, Levanon D, Groner Y, Boscolo E, Pan D, Liu PP, Lu QR, Ratner N, Huang G, Wu J. Hall A, et al. Among authors: huang g. Sci Adv. 2019 Apr 24;5(4):eaau8389. doi: 10.1126/sciadv.aau8389. eCollection 2019 Apr. Sci Adv. 2019. PMID: 31032403 Free PMC article.
Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.
Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, Spinner RJ, Largaespada DA, Ratner N. Wu J, et al. Among authors: huang g. Cell Rep. 2016 Mar 1;14(8):1979-90. doi: 10.1016/j.celrep.2016.01.074. Epub 2016 Feb 18. Cell Rep. 2016. PMID: 26904939 Free PMC article.
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.
Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G, He C, Yang J, Chen J. Huang H, et al. Among authors: huang g. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867593 Free PMC article.
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway.
Chen S, Wang Q, Yu H, Capitano ML, Vemula S, Nabinger SC, Gao R, Yao C, Kobayashi M, Geng Z, Fahey A, Henley D, Liu SZ, Barajas S, Cai W, Wolf ER, Ramdas B, Cai Z, Gao H, Luo N, Sun Y, Wong TN, Link DC, Liu Y, Boswell HS, Mayo LD, Huang G, Kapur R, Yoder MC, Broxmeyer HE, Gao Z, Liu Y. Chen S, et al. Among authors: huang g. Nat Commun. 2019 Dec 11;10(1):5649. doi: 10.1038/s41467-019-13542-2. Nat Commun. 2019. PMID: 31827082 Free PMC article.
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Farshidfar F, et al. Among authors: huang g. Nat Commun. 2022 Feb 23;13(1):898. doi: 10.1038/s41467-022-28566-4. Nat Commun. 2022. PMID: 35197475 Free PMC article.
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.
Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A. Sashida G, et al. Among authors: huang g. Nat Commun. 2014 Jun 23;5:4177. doi: 10.1038/ncomms5177. Nat Commun. 2014. PMID: 24953053 Free article.
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