Huang DCS - Search Results

1

Infection with flaviviruses requires BCLXL for cell survival.

Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y. Suzuki T, et al. Among authors: huang dcs. PLoS Pathog. 2018 Sep 27;14(9):e1007299. doi: 10.1371/journal.ppat.1007299. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30261081 Free PMC article.

2

How the Bcl-2 family of proteins interact to regulate apoptosis.

van Delft MF, Huang DC. van Delft MF, et al. Cell Res. 2006 Feb;16(2):203-13. doi: 10.1038/sj.cr.7310028. Cell Res. 2006. PMID: 16474435 Review.

3

Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.

Kvansakul M, Wei AH, Fletcher JI, Willis SN, Chen L, Roberts AW, Huang DC, Colman PM. Kvansakul M, et al. PLoS Pathog. 2010 Dec 23;6(12):e1001236. doi: 10.1371/journal.ppat.1001236. PLoS Pathog. 2010. PMID: 21203485 Free PMC article.

4

Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.

Okamoto T, Campbell S, Mehta N, Thibault J, Colman PM, Barry M, Huang DC, Kvansakul M. Okamoto T, et al. J Virol. 2012 Nov;86(21):11501-11. doi: 10.1128/JVI.01115-12. Epub 2012 Aug 15. J Virol. 2012. PMID: 22896610 Free PMC article.

5

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. Okamoto T, et al. ACS Chem Biol. 2013 Feb 15;8(2):297-302. doi: 10.1021/cb3005403. Epub 2012 Dec 10. ACS Chem Biol. 2013. PMID: 23151250

6

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.

Okamoto T, Coultas L, Metcalf D, van Delft MF, Glaser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Huang DC. Okamoto T, et al. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):261-6. doi: 10.1073/pnas.1321259110. Epub 2013 Dec 20. Proc Natl Acad Sci U S A. 2014. PMID: 24363325 Free PMC article.

7

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Kelly GL, et al. Genes Dev. 2014 Jan 1;28(1):58-70. doi: 10.1101/gad.232009.113. Genes Dev. 2014. PMID: 24395247 Free PMC article.

8

Further insights into the effects of pre-organizing the BimBH3 helix.

Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. Okamoto T, et al. ACS Chem Biol. 2014 Mar 21;9(3):838-9. doi: 10.1021/cb400638p. Epub 2014 Feb 18. ACS Chem Biol. 2014. PMID: 24547872 No abstract available.

9

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.

Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF. Djajawi TM, et al. Among authors: huang dcs, huang as. Cell Death Differ. 2020 Aug;27(8):2484-2499. doi: 10.1038/s41418-020-0517-0. Epub 2020 Feb 24. Cell Death Differ. 2020. PMID: 32094511 Free PMC article.

10

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X_L and BCL-2.

Roy MJ, Vom A, Okamoto T, Smith BJ, Birkinshaw RW, Yang H, Abdo H, White CA, Segal D, Huang DCS, Baell JB, Colman PM, Czabotar PE, Lessene G. Roy MJ, et al. Among authors: huang dcs. J Med Chem. 2021 May 13;64(9):5447-5469. doi: 10.1021/acs.jmedchem.0c01771. Epub 2021 Apr 27. J Med Chem. 2021. PMID: 33904752

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