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Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.
Chen HH, Wang TC, Lee YC, Shen PT, Chang JY, Yeh TK, Huang CH, Chang HH, Cheng SY, Lin CY, Shih C, Chen CT, Liu WM, Chen CH, Kuo CC. Chen HH, et al. Among authors: huang ch. Chem Res Toxicol. 2015 Sep 21;28(9):1681-92. doi: 10.1021/acs.chemrestox.5b00085. Epub 2015 Aug 24. Chem Res Toxicol. 2015. PMID: 26275128
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.
Chen HH, Chang HH, Chang JY, Tang YC, Cheng YC, Lin LM, Cheng SY, Huang CH, Sun MW, Chen CT, Kuo CC. Chen HH, et al. Among authors: huang ch. Free Radic Biol Med. 2017 Dec;113:505-518. doi: 10.1016/j.freeradbiomed.2017.10.375. Epub 2017 Nov 5. Free Radic Biol Med. 2017. PMID: 29080842
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Yeh TK, Song JS, Chang PW, Yu JC, Chang CH, Liao FY, Tien YW, Kuppusamy R, Li AS, Chen CH, Chen CW, Lin LM, Chang HH, Huang CH, Yao JY, Wu MH, Peng YH, Hsueh CC, Hsiao WC, Chen PH, Lin CY, Hsieh SH, Shih C, Hung MS, Wu SY, Kuo CC, Ueng SH. Yeh TK, et al. Among authors: huang ch. Eur J Med Chem. 2022 Feb 5;229:114043. doi: 10.1016/j.ejmech.2021.114043. Epub 2021 Dec 8. Eur J Med Chem. 2022. PMID: 34929581
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.
Tsai TY, Hsu T, Chen CT, Cheng JH, Yeh TK, Chen X, Huang CY, Chang CN, Yeh KC, Hsieh SH, Chien CH, Chang YW, Huang CH, Huang YW, Huang CL, Wu SH, Wang MH, Lu CT, Chao YS, Jiaang WT. Tsai TY, et al. Among authors: huang yw, huang cl, huang ch, huang cy. Bioorg Med Chem. 2009 Mar 15;17(6):2388-99. doi: 10.1016/j.bmc.2009.02.020. Epub 2009 Feb 20. Bioorg Med Chem. 2009. PMID: 19261480
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.
Tsai TY, Hsu T, Chen CT, Cheng JH, Chiou MC, Huang CH, Tseng YJ, Yeh TK, Huang CY, Yeh KC, Huang YW, Wu SH, Wang MH, Chen X, Chao YS, Jiaang WT. Tsai TY, et al. Among authors: huang yw, huang ch, huang cy. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1908-12. doi: 10.1016/j.bmcl.2009.02.061. Epub 2009 Feb 21. Bioorg Med Chem Lett. 2009. PMID: 19269819
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Yeh TK, Tsai TY, Hsu T, Cheng JH, Chen X, Song JS, Shy HS, Chiou MC, Chien CH, Tseng YJ, Huang CY, Yeh KC, Huang YL, Huang CH, Huang YW, Wang MH, Tang HK, Chao YS, Chen CT, Jiaang WT. Yeh TK, et al. Among authors: huang yl, huang yw, huang ch, huang cy. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600. doi: 10.1016/j.bmcl.2010.04.124. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483603
3,419 results