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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways.
Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Basile G, et al. Among authors: hu j. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. Cell Metab. 2023. PMID: 37339634 Free PMC article.
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN. Ueki K, et al. Among authors: hu j. Nat Genet. 2006 May;38(5):583-8. doi: 10.1038/ng1787. Epub 2006 Apr 23. Nat Genet. 2006. PMID: 16642022
Insulin signaling in alpha cells modulates glucagon secretion in vivo.
Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN. Kawamori D, et al. Among authors: hu j. Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007. Cell Metab. 2009. PMID: 19356716 Free PMC article.
Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.
Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Borowiec M, et al. Among authors: hu j. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14460-5. doi: 10.1073/pnas.0906474106. Epub 2009 Aug 10. Proc Natl Acad Sci U S A. 2009. PMID: 19667185 Free PMC article.
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