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Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity.
Zhang B, Sun J, Yuan Y, Ji D, Sun Y, Liu Y, Li S, Zhu X, Wu X, Hu J, Xie Q, Wu L, Liu L, Cheng B, Zhang Y, Jiang L, Zhao L, Yu F, Song W, Wang M, Xu Y, Ma S, Fei Y, Zhang L, Zhou D, Zhang X. Zhang B, et al. Among authors: hu j. Signal Transduct Target Ther. 2023 Jan 23;8(1):28. doi: 10.1038/s41392-022-01208-3. Signal Transduct Target Ther. 2023. PMID: 36690610 Free PMC article.
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells.
Zhang B, Sun J, Wang Y, Ji D, Yuan Y, Li S, Sun Y, Hou Y, Li P, Zhao L, Yu F, Ma W, Cheng B, Wu L, Hu J, Wang M, Song W, Li X, Li H, Fei Y, Chen H, Zhang L, Tsokos GC, Zhou D, Zhang X. Zhang B, et al. Among authors: hu j. Nat Biomed Eng. 2021 Nov;5(11):1288-1305. doi: 10.1038/s41551-021-00797-8. Epub 2021 Sep 27. Nat Biomed Eng. 2021. PMID: 34580438
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator.
Zhang B, Wang Y, Huang S, Sun J, Wang M, Ma W, You Y, Wu L, Hu J, Song W, Liu X, Li S, Chen H, Zhang G, Zhang L, Zhou D, Li L, Zhang X. Zhang B, et al. Among authors: hu j. Cell Chem Biol. 2021 Jan 21;28(1):60-69.e7. doi: 10.1016/j.chembiol.2020.10.004. Epub 2020 Oct 27. Cell Chem Biol. 2021. PMID: 33113407 Free article.
Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Zhu T, Fang BY, Meng XB, Zhang SX, Wang H, Gao G, Liu F, Wu Y, Hu J, Sun GB, Sun XB. Zhu T, et al. Among authors: hu j. Pharm Biol. 2022 Dec;60(1):195-205. doi: 10.1080/13880209.2021.2014895. Pharm Biol. 2022. PMID: 35060427 Free PMC article.
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