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A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.
Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X. Liu P, et al. Among authors: hu j. Hepatology. 2017 Jul;66(1):167-181. doi: 10.1002/hep.29183. Epub 2017 May 22. Hepatology. 2017. PMID: 28370287 Free PMC article.
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.
Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Zhang S, et al. Among authors: hu j. J Hepatol. 2017 Dec;67(6):1194-1203. doi: 10.1016/j.jhep.2017.07.006. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733220 Free PMC article.
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