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Page 1
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.
Hu DX, Patel S, Chen H, Wang S, Staben ST, Dimitrova YN, Wallweber HA, Lee JY, Chan GKY, Sneeringer CJ, Prangley MS, Moffat JG, Wu KC, Schutt LK, Salphati L, Pang J, McNamara E, Huang H, Chen Y, Wang Y, Zhao W, Lim J, Murthy A, Siu M. Hu DX, et al. J Med Chem. 2022 Sep 8;65(17):11500-11512. doi: 10.1021/acs.jmedchem.1c01180. Epub 2021 Nov 15. J Med Chem. 2022. PMID: 34779204
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
Leger PR, Hu DX, Biannic B, Bui M, Han X, Karbarz E, Maung J, Okano A, Osipov M, Shibuya GM, Young K, Higgs C, Abraham B, Bradford D, Cho C, Colas C, Jacobson S, Ohol YM, Pookot D, Rana P, Sanchez J, Shah N, Sun M, Wong S, Brockstedt DG, Kassner PD, Schwarz JB, Wustrow DJ. Leger PR, et al. Among authors: hu dx. J Med Chem. 2020 May 28;63(10):5398-5420. doi: 10.1021/acs.jmedchem.0c00245. Epub 2020 May 6. J Med Chem. 2020. PMID: 32302140
Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors.
Robles O, Jackson JJ, Marshall L, Talay O, Chian D, Cutler G, Diokno R, Hu DX, Jacobson S, Karbarz E, Kassner PD, Ketcham JM, McKinnell J, Meleza C, Reilly MK, Riegler E, Shunatona HP, Wadsworth A, Younai A, Brockstedt DG, Wustrow DJ, Zibinsky M. Robles O, et al. Among authors: hu dx. J Med Chem. 2020 Aug 13;63(15):8584-8607. doi: 10.1021/acs.jmedchem.0c00988. Epub 2020 Jul 28. J Med Chem. 2020. PMID: 32667798
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
Jackson JJ, Ketcham JM, Younai A, Abraham B, Biannic B, Beck HP, Bui MHT, Chian D, Cutler G, Diokno R, Hu DX, Jacobson S, Karbarz E, Kassner PD, Marshall L, McKinnell J, Meleza C, Okal A, Pookot D, Reilly MK, Robles O, Shunatona HP, Talay O, Walker JR, Wadsworth A, Wustrow DJ, Zibinsky M. Jackson JJ, et al. Among authors: hu dx. J Med Chem. 2019 Jul 11;62(13):6190-6213. doi: 10.1021/acs.jmedchem.9b00506. Epub 2019 Jul 1. J Med Chem. 2019. PMID: 31259550
Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy.
Jackson JJ, Shibuya GM, Ravishankar B, Adusumilli L, Bradford D, Brockstedt DG, Bucher C, Bui M, Cho C, Colas C, Cutler G, Dukes A, Han X, Hu DX, Jacobson S, Kassner PD, Katibah GE, Ko MYM, Kolhatkar U, Leger PR, Ma A, Marshall L, Maung J, Ng AA, Okano A, Pookot D, Poon D, Ramana C, Reilly MK, Robles O, Schwarz JB, Shakhmin AA, Shunatona HP, Sreenivasan R, Tivitmahaisoon P, Xu M, Zaw T, Wustrow DJ, Zibinsky M. Jackson JJ, et al. Among authors: hu dx. J Med Chem. 2022 Oct 13;65(19):12895-12924. doi: 10.1021/acs.jmedchem.2c00736. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36127295
Therapeutic role of neural stem cells in neurological diseases.
Yang L, Liu SC, Liu YY, Zhu FQ, Xiong MJ, Hu DX, Zhang WJ. Yang L, et al. Among authors: hu dx. Front Bioeng Biotechnol. 2024 Mar 7;12:1329712. doi: 10.3389/fbioe.2024.1329712. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38515621 Free PMC article. Review.
[Diagnosis status and genetic characteristics analysis of Fanconi anemia in China].
Li N, Hu DX, Qin X, Zhu YP, Zhou M, He L, Chang LX, Xu XJ, Dai Y, Cao XY, Chen K, Wang HM, Wang CJ, He YL, Qian XW, Xu LP, Chen J. Li N, et al. Among authors: hu dx. Zhonghua Er Ke Za Zhi. 2023 Oct 2;61(10):889-895. doi: 10.3760/cma.j.cn112140-20230606-00383. Zhonghua Er Ke Za Zhi. 2023. PMID: 37803855 Chinese.
Potential role of Schwann cells in neuropathic pain.
Zhang WJ, Liu SC, Ming LG, Yu JW, Zuo C, Hu DX, Luo HL, Zhang Q. Zhang WJ, et al. Among authors: hu dx. Eur J Pharmacol. 2023 Oct 5;956:175955. doi: 10.1016/j.ejphar.2023.175955. Epub 2023 Aug 2. Eur J Pharmacol. 2023. PMID: 37541365 Review.
92 results