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Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signalling pathway in a rat model.
Zhou CH, Shi ZL, Meng JH, Hu B, Zhao CC, Yang YT, Yu W, Chen ZX, Heng BC, Parkman VA, Jiang S, Zhu HX, Wu HB, Shen WL, Yan SG. Zhou CH, et al. Among authors: hu b. Br J Pharmacol. 2018 Mar;175(6):859-876. doi: 10.1111/bph.14092. Epub 2018 Feb 14. Br J Pharmacol. 2018. PMID: 29130485 Free PMC article.
Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling.
Hu B, Sun X, Yang Y, Ying Z, Meng J, Zhou C, Jiang G, Li S, Wu F, Zhao X, Zhu H, Wu H, Cai X, Shi Z, Yan S. Hu B, et al. FASEB J. 2019 Feb;33(2):2574-2586. doi: 10.1096/fj.201800920R. Epub 2018 Oct 4. FASEB J. 2019. PMID: 30285579
At the molecular level, tomatidine abrogated phosphorylation of c-Jun N-terminal kinase (JNK)/p38, NF-kappaB, and protein kinase B (Akt) pathway proteins by suppressing RANK expression, inhibiting the binding of TRAF6 to RANK, and downregulating the osteoclastogenesis mark …
At the molecular level, tomatidine abrogated phosphorylation of c-Jun N-terminal kinase (JNK)/p38, NF-kappaB, and protein kinase B (A …
Octyl itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling.
Sun X, Zhang B, Pan X, Huang H, Xie Z, Ma Y, Hu B, Wang J, Chen Z, Shi P. Sun X, et al. Among authors: hu b. FASEB J. 2019 Nov;33(11):12929-12940. doi: 10.1096/fj.201900887RR. Epub 2019 Sep 6. FASEB J. 2019. PMID: 31490085 Free PMC article.
In summary, OI, an itaconate derivative, can inhibit osteoclastogenesis in vitro and in vivo, indicating that OI could be a potential drug to treat osteoclast-related diseases; our results also link itaconate to the development of osteoporosis.-Sun, X., Zhang, B., Pan, X., …
In summary, OI, an itaconate derivative, can inhibit osteoclastogenesis in vitro and in vivo, indicating that OI could be a potential drug t …
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