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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR Jr. Hsu T, et al. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12420-5. doi: 10.1073/pnas.1635213100. Epub 2003 Oct 13. Proc Natl Acad Sci U S A. 2003. PMID: 14557547 Free PMC article.
Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.
Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR Jr. Sambandamurthy VK, et al. Among authors: hsu t. Vaccine. 2006 Sep 11;24(37-39):6309-20. doi: 10.1016/j.vaccine.2006.05.097. Epub 2006 Jun 12. Vaccine. 2006. PMID: 16860907
Sulfite reduction in mycobacteria.
Pinto R, Harrison JS, Hsu T, Jacobs WR Jr, Leyh TS. Pinto R, et al. Among authors: hsu t. J Bacteriol. 2007 Sep;189(18):6714-22. doi: 10.1128/JB.00487-07. Epub 2007 Jul 20. J Bacteriol. 2007. PMID: 17644602 Free PMC article.
Einstein Contained Aerosol Pulmonizer (ECAP): Improved Biosafety for Multi-Drug Resistant (MDR) and Extensively Drug Resistant (XDR) Mycobacterium tuberculosis Aerosol Infection Studies.
Chen B, Weisbrod TR, Hsu T, Sambandamurthy V, Vieira-Cruz D, Chibbaro A, Ghidoni D, Kile T, Barkley WE, Vilchèze C, Colon-Berezin C, Thaler DS, Larsen MH, Sturm AW, Jacobs WR Jr. Chen B, et al. Among authors: hsu t. Appl Biosaf. 2011 Oct 27;16(3):134-138. doi: 10.1177/153567601101600302. Appl Biosaf. 2011. PMID: 23413363 Free PMC article.
2,809 results