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Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
Mackman RL, Kalla RV, Babusis D, Pitts J, Barrett KT, Chun K, Du Pont V, Rodriguez L, Moshiri J, Xu Y, Lee M, Lee G, Bleier B, Nguyen AQ, O'Keefe BM, Ambrosi A, Cook M, Yu J, Dempah KE, Bunyan E, Riola NC, Lu X, Liu R, Davie A, Hsiang TY, Dearing J, Vermillion M, Gale M Jr, Niedziela-Majka A, Feng JY, Hedskog C, Bilello JP, Subramanian R, Cihlar T. Mackman RL, et al. Among authors: hsiang ty. J Med Chem. 2023 Sep 14;66(17):11701-11717. doi: 10.1021/acs.jmedchem.3c00750. Epub 2023 Aug 19. J Med Chem. 2023. PMID: 37596939
Duration of viral infectiousness and correlation with symptoms and diagnostic testing in non-hospitalized adults during acute SARS-CoV-2 infection: A longitudinal cohort study.
Drain PK, Dalmat RR, Hao L, Bemer MJ, Budiawan E, Morton JF, Ireton RC, Hsiang TY, Marfatia Z, Prabhu R, Woosley C, Gichamo A, Rechkina E, Hamilton D, Montaño M, Cantera JL, Ball AS, Golez I, Smith E, Greninger AL, McElrath MJ, Thompson M, Grant BD, Meisner A, Gottlieb GS, Gale M Jr. Drain PK, et al. Among authors: hsiang ty. J Clin Virol. 2023 Apr;161:105420. doi: 10.1016/j.jcv.2023.105420. Epub 2023 Mar 3. J Clin Virol. 2023. PMID: 36913789 Free PMC article.
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron.
Hao L, Hsiang TY, Dalmat RR, Ireton R, Morton JF, Stokes C, Netland J, Hale M, Thouvenel C, Wald A, Franko NM, Huden K, Chu HY, Sigal A, Greninger AL, Tilles S, Barrett LK, Van Voorhis WC, Munt J, Scobey T, Baric RS, Rawlings DJ, Pepper M, Drain PK, Gale M Jr. Hao L, et al. Among authors: hsiang ty. Viruses. 2023 Feb 14;15(2):530. doi: 10.3390/v15020530. Viruses. 2023. PMID: 36851745 Free PMC article.
A C57BL/6 Mouse Model of SARS-CoV-2 Infection Recapitulates Age- and Sex-Based Differences in Human COVID-19 Disease and Recovery.
Davis MA, Voss K, Turnbull JB, Gustin AT, Knoll M, Muruato A, Hsiang TY, Dinnon Iii KH, Leist SR, Nickel K, Baric RS, Ladiges W, Akilesh S, Smith KD, Gale M Jr. Davis MA, et al. Among authors: hsiang ty. Vaccines (Basel). 2022 Dec 25;11(1):47. doi: 10.3390/vaccines11010047. Vaccines (Basel). 2022. PMID: 36679892 Free PMC article.
Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity.
Bhatraju PK, Morrell ED, Stanaway IB, Sathe NA, Srivastava A, Postelnicu R, Green R, Andrews A, Gonzalez M, Kratochvil CJ, Kumar VK, Hsiang TY, Gale M Jr, Anesi GL, Wyles D, Broadhurst MJ, Brett-Major D, Mukherjee V, Sevransky JE, Landsittel D, Hung C, Altemeier WA, Gharib SA, Uyeki TM, Cobb JP, Liebler JM, Crosslin DR, Jarvik GP, Segal LN, Evans L, Mikacenic C, Wurfel MM. Bhatraju PK, et al. Among authors: hsiang ty. Crit Care Explor. 2022 Dec 30;5(1):e0827. doi: 10.1097/CCE.0000000000000827. eCollection 2023 Jan. Crit Care Explor. 2022. PMID: 36600780 Free PMC article.
A C57BL/6 Mouse model of SARS-CoV-2 infection recapitulates age- and sex-based differences in human COVID-19 disease and recovery.
Davis M, Voss K, Turnbull JB, Gustin AT, Knoll M, Muruato A, Hsiang TY, Dinnon KH 3rd, Leist SR, Nickel K, Baric RS, Ladiges W, Akilesh S, Smith KD, Gale M. Davis M, et al. Among authors: hsiang ty. Res Sq [Preprint]. 2022 Nov 14:rs.3.rs-2194450. doi: 10.21203/rs.3.rs-2194450/v1. Res Sq. 2022. PMID: 36415465 Free PMC article. Updated. Preprint.
Dynamics of SARS-CoV-2 VOC neutralization and novel mAb reveal protection against Omicron.
Hao L, Hsiang TY, Dalmat RR, Ireton R, Morton J, Stokes C, Netland J, Hale M, Thouvenel C, Wald A, Franko NM, Huden K, Chu H, Greninger A, Tilles S, Barrett LK, Van Voorhis WC, Munt J, Scobey T, Baric RS, Rawlings D, Pepper M, Drain PK, Gale M. Hao L, et al. Among authors: hsiang ty. medRxiv [Preprint]. 2022 Aug 16:2022.08.12.22278720. doi: 10.1101/2022.08.12.22278720. medRxiv. 2022. PMID: 36032965 Free PMC article. Updated. Preprint.
Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine.
Hawman DW, Meade-White K, Clancy C, Archer J, Hinkley T, Leventhal SS, Rao D, Stamper A, Lewis M, Rosenke R, Krieger K, Randall S, Khandhar AP, Hao L, Hsiang TY, Greninger AL, Gale M Jr, Berglund P, Fuller DH, Rosenke K, Feldmann H, Erasmus JH. Hawman DW, et al. Among authors: hsiang ty. EBioMedicine. 2022 Sep;83:104196. doi: 10.1016/j.ebiom.2022.104196. Epub 2022 Aug 4. EBioMedicine. 2022. PMID: 35932641 Free PMC article.
Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants.
Beavis AC, Li Z, Briggs K, Huertas-Díaz MC, Wrobel ER, Najera M, An D, Orr-Burks N, Murray J, Patil P, Huang J, Mousa J, Hao L, Hsiang TY, Gale M Jr, Harvey SB, Tompkins SM, Hogan RJ, Lafontaine ER, Jin H, He B. Beavis AC, et al. Among authors: hsiang ty. bioRxiv [Preprint]. 2022 Jun 8:2022.06.07.495215. doi: 10.1101/2022.06.07.495215. bioRxiv. 2022. PMID: 35702147 Free PMC article. Preprint.
42 results