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MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.
Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, John ARO. Edwards RL, et al. Among authors: hruz pw. Sci Rep. 2017 Aug 21;7(1):8400. doi: 10.1038/s41598-017-07159-y. Sci Rep. 2017. PMID: 28827774 Free PMC article.
A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.
Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW. Kraft TE, et al. Among authors: hruz pw. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. doi: 10.1128/AAC.00218-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27736766 Free PMC article.
Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.
Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MXG, Odom John AR, Hruz PW. Heitmeier MR, et al. Among authors: hruz pw. PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019. PLoS One. 2019. PMID: 31071153 Free PMC article.
60 results