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Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. Lagnado A, et al. Among authors: hruby a. EMBO J. 2021 May 3;40(9):e106048. doi: 10.15252/embj.2020106048. Epub 2021 Mar 25. EMBO J. 2021. PMID: 33764576 Free PMC article.
Characterization of cellular senescence in aging skeletal muscle.
Zhang X, Habiballa L, Aversa Z, Ng YE, Sakamoto AE, Englund DA, Pearsall VM, White TA, Robinson MM, Rivas DA, Dasari S, Hruby AJ, Lagnado AB, Jachim SK, Granic A, Sayer AA, Jurk D, Lanza IR, Khosla S, Fielding RA, Nair KS, Schafer MJ, Passos JF, LeBrasseur NK. Zhang X, et al. Among authors: hruby aj. Nat Aging. 2022 Jul;2(7):601-615. doi: 10.1038/s43587-022-00250-8. Epub 2022 Jul 15. Nat Aging. 2022. PMID: 36147777 Free PMC article.
Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study.
Habiballa L, Hruby A, Granic A, Dodds RM, Hillman SJ, Jurk D, Passos JF, Sayer AA. Habiballa L, et al. Among authors: hruby a. Geroscience. 2024 Feb;46(1):1141-1158. doi: 10.1007/s11357-023-00869-4. Epub 2023 Jul 11. Geroscience. 2024. PMID: 37434081 Free PMC article.
Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff M, Hruby A, Averbukh M, Alcala A, Dutta N, Torres TC, Moaddeli D, Vega M, Kim J, Bong A, Coakley AJ, Hicks D, Wang J, Wang T, Hoang S, Tharp KM, Garcia G, Higuchi-Sanabria R. Oorloff M, et al. Among authors: hruby a. bioRxiv [Preprint]. 2024 Apr 12:2024.04.11.589121. doi: 10.1101/2024.04.11.589121. bioRxiv. 2024. PMID: 38645203 Free PMC article. Preprint.
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging.
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Dutta N, et al. Among authors: hruby a. Geroscience. 2024 Apr 3. doi: 10.1007/s11357-024-01144-w. Online ahead of print. Geroscience. 2024. PMID: 38570396
Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Castro Torres T, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Dutta N, et al. Among authors: hruby a. bioRxiv [Preprint]. 2023 Nov 27:2023.11.27.568896. doi: 10.1101/2023.11.27.568896. bioRxiv. 2023. PMID: 38077060 Free PMC article. Preprint.
Glial-derived mitochondrial signals affect neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. Among authors: hruby a. Sci Adv. 2023 Oct 13;9(41):eadi1411. doi: 10.1126/sciadv.adi1411. Epub 2023 Oct 13. Sci Adv. 2023. PMID: 37831769 Free PMC article.
69 results