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Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Menalled L, El-Khodor BF, Patry M, Suárez-Fariñas M, Orenstein SJ, Zahasky B, Leahy C, Wheeler V, Yang XW, MacDonald M, Morton AJ, Bates G, Leeds J, Park L, Howland D, Signer E, Tobin A, Brunner D. Menalled L, et al. Among authors: howland d. Neurobiol Dis. 2009 Sep;35(3):319-36. doi: 10.1016/j.nbd.2009.05.007. Epub 2009 May 21. Neurobiol Dis. 2009. PMID: 19464370 Free PMC article.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM. Gafni J, et al. Among authors: howland d. J Neurosci. 2012 May 30;32(22):7454-65. doi: 10.1523/JNEUROSCI.6379-11.2012. J Neurosci. 2012. PMID: 22649225 Free PMC article.
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
Menalled LB, Kudwa AE, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio W, McConnell K, Connor D, Murphy C, Oakeshott S, Kwan M, Beltran J, Ghavami A, Brunner D, Park LC, Ramboz S, Howland D. Menalled LB, et al. Among authors: howland d. PLoS One. 2012;7(12):e49838. doi: 10.1371/journal.pone.0049838. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284626 Free PMC article.
Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.
Heikkinen T, Lehtimäki K, Vartiainen N, Puoliväli J, Hendricks SJ, Glaser JR, Bradaia A, Wadel K, Touller C, Kontkanen O, Yrjänheikki JM, Buisson B, Howland D, Beaumont V, Munoz-Sanjuan I, Park LC. Heikkinen T, et al. Among authors: howland d. PLoS One. 2012;7(12):e50717. doi: 10.1371/journal.pone.0050717. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284644 Free PMC article.
High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease.
Balci F, Oakeshott S, Shamy JL, El-Khodor BF, Filippov I, Mushlin R, Port R, Connor D, Paintdakhi A, Menalled L, Ramboz S, Howland D, Kwak S, Brunner D. Balci F, et al. Among authors: howland d. PLoS Curr. 2013 Jul 11;5:ecurrents.hd.124aa0d16753f88215776fba102ceb29. doi: 10.1371/currents.hd.124aa0d16753f88215776fba102ceb29. PLoS Curr. 2013. PMID: 23863947 Free PMC article.
161 results