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Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Among authors: howitz kt. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.
Design and synthesis of compounds that extend yeast replicative lifespan.
Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA. Yang H, et al. Among authors: howitz kt. Aging Cell. 2007 Feb;6(1):35-43. doi: 10.1111/j.1474-9726.2006.00259.x. Epub 2006 Dec 5. Aging Cell. 2007. PMID: 17156081 Free PMC article.
Identification and characterization of novel sirtuin inhibitor scaffolds.
Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K, Marmorstein R. Sanders BD, et al. Bioorg Med Chem. 2009 Oct 1;17(19):7031-41. doi: 10.1016/j.bmc.2009.07.073. Epub 2009 Aug 3. Bioorg Med Chem. 2009. PMID: 19734050 Free PMC article.
Assay development for histone methyltransferases.
Horiuchi KY, Eason MM, Ferry JJ, Planck JL, Walsh CP, Smith RF, Howitz KT, Ma H. Horiuchi KY, et al. Among authors: howitz kt. Assay Drug Dev Technol. 2013 May;11(4):227-36. doi: 10.1089/adt.2012.480. Epub 2013 Apr 4. Assay Drug Dev Technol. 2013. PMID: 23557020 Free PMC article.
15 results