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Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells.
Alaqbi SS, Burke L, Guterman I, Green C, West K, Palacios-Gallego R, Cai H, Alexandrou C, Myint NNM, Parrott E, Howells LM, Higgins JA, Jones DJL, Singh R, Britton RG, Tufarelli C, Thomas A, Rufini A. Alaqbi SS, et al. Among authors: howells lm. PLoS One. 2022 Feb 7;17(2):e0262364. doi: 10.1371/journal.pone.0262364. eCollection 2022. PLoS One. 2022. PMID: 35130302 Free PMC article.
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.
Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D, Miller AS, Brown K, Gescher AJ, Steward WP. Irving GR, et al. Among authors: howells lm. Cancer Prev Res (Phila). 2013 Feb;6(2):119-28. doi: 10.1158/1940-6207.CAPR-12-0281. Epub 2012 Dec 11. Cancer Prev Res (Phila). 2013. PMID: 23233733 Free PMC article. Clinical Trial.
Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note.
James MI, Howells LM, Karmokar A, Higgins JA, Greaves P, Cai H, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Brown K. James MI, et al. Among authors: howells lm. PLoS One. 2015 Feb 6;10(2):e0117776. doi: 10.1371/journal.pone.0117776. eCollection 2015. PLoS One. 2015. PMID: 25658706 Free PMC article.
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.
James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, Griffin-Teal N, Thomas A, Greaves P, Cai H, Patel SR, Morgan B, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Howells LM, Brown K. James MI, et al. Among authors: howells lm. Cancer Lett. 2015 Aug 10;364(2):135-41. doi: 10.1016/j.canlet.2015.05.005. Epub 2015 May 12. Cancer Lett. 2015. PMID: 25979230 Free PMC article. Clinical Trial.
67 results